Effect of goserelin acetate on non-invasive indices of hepatic steatosis in women with endometriosis

Dimitrios A. Anastasilakis, Athanasios D. Anastasilakis, Athina Gkiomisi, Anastasios Semertzidis, Panagiotis Nikolakopoulos, Stergios Papachatzopoulos, Aris Daniilidis, Dimitrios G. Goulis, Antonis Goulas, Stergios A. Pοlyzos
In: Research Square · 2025 · doi:10.21203/rs.3.rs-7566446/v1 · W4414551138
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study evaluated non-invasive hepatic steatosis indices in premenopausal women with endometriosis before, during, and after goserelin treatment, finding no significant changes except for MetS-IR, which lacked significant pairwise differences.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This post-hoc analysis studied premenopausal women with histologically verified endometriosis (n=21) treated for 6 months with goserelin acetate to induce pharmacologic menopause, then assessed again 6 months after discontinuation, comparing baseline, estrogen-deficient, and estrogen-replenishment time points using non-invasive indices of hepatic steatosis and fibrosis. Matched premenopausal controls (n=27) with no endometriosis were recruited for baseline comparisons, and hepatic steatosis was estimated using multiple serum-based indices (e.g., HSI, TyG-related indices, MetS-IR, DSI, FSI), with fibrosis assessed via BMI–AST/ALT ratio Diabetes Mellitus (BARD). Overall, steatosis indices and BARD did not show significant change after goserelin-induced estrogen deficiency, with only MetS-IR showing a nominal overall change that was not significant in Bonferroni-corrected pairwise comparisons; lipid profiles and insulin resistance worsened during the study. This paper is centrally about endometriosis — it evaluates whether goserelin-induced estrogen deficiency in women with endometriosis alters non-invasive measures of hepatic steatosis and fibrosis.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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