Prostaglandin levels in menstrual fluid of nondysmenorrheic and of dysmenorrheic subjects with and without oral contraceptive or ibuprofen therapy

W Y Chan, WY Chan, Dawood MY, M Y Dawood
Advances in prostaglandin and thromboxane research · 1980 · vol. 8 , pp. 1443–7 · PMID:7376995 · W2409543013
RCT OA: closed CC0 ⤵ 21 in-corpus citations
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Dysmenorrheic women had higher menstrual fluid volume and prostaglandin release, which ibuprofen therapy significantly reduced, indicating prostaglandins, not fluid volume, cause dysmenorrhea symptoms.

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Abstract

Results of a continuing study on dysmenorrhea are reported. 10 subjects were monitored for this study. 2 were normal nondysmenorrheic women 6 were dysmenorrheic and participated in an Ibuprofen trial and the remaining 2 were mildly dysmenorrheic-severely dysmenorrheic whose symptoms had abated on oral contraceptive therapy. Menstrual fluid volume and prostaglandin (PG) production were measured in the 3 groups; in the dysmenorrheic women (n=6) who were not treated with oral contraceptives significantly higher menstrual fluid volume and menstrual PG release were measured compared with controls and oral contraceptive-treated women. The 6 dysmenorrheic women previously untreated were then enrolled in a standard double-blind cross-over study using Ibuprofen and placebo. 28 cycles were monitored. Ibuprofen administrated prophylactically 400 mg 4 times/day considerably reduced the PG release in menstrual fluid but not the volume of menstrual fluid. Hence it is concluded that primary dysmenorrheic symptoms are caused by high PG levels in menstrual fluid not by fluid volume.

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Condition tags

dysmenorrhea

MeSH descriptors

Dysmenorrhea Ibuprofen Menstruation Menstruation Adult Contraceptives, Oral Contraceptives, Oral Double-Blind Method Dysmenorrhea Dysmenorrhea Extracellular Space Extracellular Space Female Humans Ibuprofen

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