Alterations in Intrauterine Pressure, Menstrual Fluid Prostaglandin F Levels, and Pain in Dysmenorrheic Women Treated With Nimesulide
article
OA: closed
CC0
⤵ 4 in-corpus citations
AI-generated summary
Nimesulide significantly decreased intrauterine pressure and menstrual fluid prostaglandin F levels in women with primary dysmenorrhea, correlating with pain relief and improved therapeutic efficacy compared to placebo.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
A double-blind crossover study was carried out to evaluate the therapeutic efficacy of nimesulide and its effects on uterine activity, menstrual fluid prostaglandin F, and pain in women suffering from primary dysmenorrhea. Twenty-three women entered the clinical pharmacologic study. Intrauterine pressure was monitored with a microballoon-tipped catheter on the first day of menstruation. During the maximal pain period (based on monitoring in six patients), nimesulide significantly decreased intrauterine pressure; the measure of pain relief was consistent with decrease of uterine activity. In another six patients, the registration of intrauterine pressure during the submaximal pain period demonstrated that both in the nimesulide- and placebo-treated cycles, the uterine activity was at a lower mean level than that registered during maximal pain. Furthermore, when two 100-mg oral doses of nimesulide were administered to 11 dysmenorrheic women, in double-blind, crossover conditions with placebo as a blank reference, it brought about a reduction of menstrual fluid prostaglandin F2 levels from 382 to 94 ng/mL, (P less than .001). Fourteen women entered a four-cycle, double-blind, crossover therapeutic trial. Each patient was randomly assigned to one of two treatment sequences with nimesulide 200 mg/d PO or placebo. The therapy was judged very effective or good in 22 of 28 cycles treated with nimesulide compared with nine of 27 cycles treated with placebo (P less than .01). The amount of bleeding during the treated cycles did not change, and there were no complaints of untoward signs or symptoms related to the therapies.
My notes (saved in your browser only)
Condition tags
Citation neighborhood (sparse)
Too few in-corpus citations on either side for a chart; here are the lists.
Cites (2)
- Prostaglandin levels in menstrual fluid of nondysmenorrheic and of dysmenorrheic subjects with and without oral contraceptive or ibuprofen therapy. 1980
- Dysmenorrhoea and Prostaglandins 1981
Cited by (4)
- Eicosanoids in primary dysmenorrhea, endometriosis and menstrual migraine 1989
- Naproxen sodium decreases prostaglandins secretion from cultured human endometrial stromal cells modulating metabolizing enzymes mRNA expression 2015
- Analysis of uterine contractility after administration of the non‐steroidal antiinflammatory drug nimesulide 1992
- Distribution of oral nimesulide in female genital tissues 1991
References (9)
- Dysmenorrhoea and Prostaglandins via openalex
- Prostaglandin levels in menstrual fluid of nondysmenorrheic and of dysmenorrheic subjects with and without oral contraceptive or ibuprofen therapy. via openalex
- W2062888336 via openalex
- W2090162376 via openalex
- W2124905805 via openalex
- W2411777360 via openalex
- W1997072488 via openalex
- W2888753827 via openalex
- W2039724533 via openalex
Cited by (4)
- Naproxen sodium decreases prostaglandins secretion from cultured human endometrial stromal cells modulating metabolizing enzymes mRNA expression 2015
- Analysis of uterine contractility after administration of the non‐steroidal antiinflammatory drug nimesulide 1992
- Distribution of oral nimesulide in female genital tissues 1991
- Eicosanoids in primary dysmenorrhea, endometriosis and menstrual migraine 1989
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- unpaywall
- last seen: 2026-08-25T06:41:39.333708+00:00
License: CC0
· commercial use OK