Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic

C A Gateley, C. Gateley, Margaret Miers, M Miers, R E Mansel, L E Hughes
Journal of the Royal Society of Medicine · 1992 · vol. 85(1) , pp. 12–15 · doi:10.1177/014107689208500105 · PMID:1548647 · PMC1293453 · W1868014125
Non-randomised trial OA: bronze CC0 ⤵ 8 in-corpus citations
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This 17-year experience at the Cardiff Mastalgia Clinic found danazol most effective for mastalgia, with bromocriptine and evening primrose oil showing equivalent efficacy but fewer adverse events for the latter.

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Abstract

Mastalgia commonly presents to medical practitioners. The majority of patients can be managed by exclusion of cancer and reassurance. In some the severity of pain affects the quality of life and drug treatment should be considered. Since its inception 324 patients with cyclical mastalgia and 90 with non-cyclical mastalgia have received a therapeutic trial of drug treatment in the Cardiff Mastalgia Clinic. Overall 92% of those with cyclical mastalgia and 64% with non-cyclical mastalgia obtained a clinically useful response to therapy. Danazol was the most effective drug, with bromocriptine and evening primrose oil having equivalent efficacy. Many fewer adverse events were complained of by patients treated with evening primrose oil than danazol or bromocriptine.

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MeSH descriptors

Anti-Inflammatory Agents, Non-Steroidal Breast Diseases Bromocriptine Danazol Fatty Acids, Essential Pain Anti-Inflammatory Agents, Non-Steroidal Breast Diseases Bromocriptine Danazol Fatty Acids, Essential Female gamma-Linolenic Acid Humans Linoleic Acids Oenothera biennis Pain Periodicity Plant Oils Treatment Outcome

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