Maintenance therapy of cyclical mastalgia using low-dose danazol.
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Low-dose danazol during the luteal phase provided complete or substantial relief for 100% of women with severe cyclical mastalgia, with no reported side effects.
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Abstract
In an open study, low-dose danazol (mean total dose 700 mg/month) was given during the luteal phase to 20 women with severe relapsing cyclical mastalgia. All subjects had previously obtained a useful clinical response on conventional dosage of danazol, but side effects occurred in 13 (65%). On the low-dose regimen, complete relief of symptoms was attained by 11 women (55%) and the remainder achieved a substantial clinical improvement; no side effects were reported. A low-dose regimen may be suitable for women with chronic relapsing cyclical mastalgia or those who develop side effects on conventional dosage.
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Cited by (6)
- Mastalgia: A narrative literature review of current understanding and management 2018
- Evaluation and Management of Breast Pain 2004
- Drug Therapy of Mastalgia 1994
- Drug Treatments for Mastalgia: 17 Years Experience in the Cardiff Mastalgia Clinic 1992
- Mastalgia refractory to drug treatment 1990
- Management of breast pain and nodularity 1989
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- openalex
- last seen: 2026-05-10T10:07:52.218738+00:00
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