High-dose, short-term glucocorticoids for the treatment of infertility resulting from premature ovarian failure

B Corenblum, Bernard Corenblum, Timothy Rowe, T Rowe, Patrick J. Taylor, P J Taylor
Fertility and sterility · 1993 · vol. 59(5) , pp. 988–991 · doi:10.1016/s0015-0282(16)55915-9 · PMID:8486200 · W65371067
Non-randomised trial OA: closed CC0 ⤵ 10 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This study investigated the efficacy of high-dose, short-term glucocorticoid treatment in addressing infertility caused by premature ovarian failure.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To evaluate prospectively the effects of high-dose, short-term treatment with a glucocorticoid in an attempt to normalize ovarian failure and induce pregnancy in women presenting with infertility. DESIGN: Uncontrolled, nonrandomized prospective study. SETTING: Two university-based reproductive endocrinology clinics. PATIENTS: Eleven consecutive women with premature ovarian failure (POF) who were desirous of pregnancy. INTERVENTIONS: Prednisone 25 mg four times per day for 2 weeks. MAIN OUTCOME MEASURES: Two women demonstrated normalization of their serum gonadotropins, an increase of serum E2, and ultrasonographic visualization of follicular growth, with both conceiving. The other nine demonstrated no biochemical or clinical response. CONCLUSIONS: Premature ovarian failure may not be an irreversible process and may either spontaneously resolve or may respond to therapeutic modalities such as high-dose glucocorticoids in selected patients. In this uncontrolled study, the results were best with women with concomitant autoimmune thyroid disease and POF of < 2 years' duration.

My notes (saved in your browser only)

Condition tags

infertility

MeSH descriptors

Infertility, Female Prednisone Primary Ovarian Insufficiency Adult Drug Administration Schedule Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Infertility, Female Infertility, Female Infertility, Female Luteinizing Hormone Luteinizing Hormone Ovarian Follicle Ovarian Follicle Ovarian Follicle Prednisone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (22)

Cited by (7)

Source provenance

openalex
last seen: 2026-05-13T18:43:51.602584+00:00
pubmed
last seen: 2026-10-08T21:59:37.277143+00:00
unpaywall
last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0 · commercial use OK