Laparoscopic uterine biopsy for diagnosing diffuse adenomyosis
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Laparoscopic uterine needle biopsy safely diagnosed adenomyosis in 19% of women with menstrual pain and 17% of asymptomatic women, with endometriosis more frequent and severe in painful subjects.
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Abstract
OBJECTIVE: To investigate the possibility of diagnosing diffuse adenomyosis with the uterus in situ.
STUDY DESIGN: Myometrial needle biopsy was performed on a prospectively evaluated series of 72 women undergoing laparoscopy for infertility and/or chronic pelvic pain. Before surgery the patients completed a questionnaire on the presence and severity of dysmenorrhea according to a linear analog and verbal rating scale. A single specimen was taken from along the median line in the upper third of the posterior uterine wall using a 14-gauge Tru-cut needle inserted through the anterior abdominal wall under laparoscopic guidance.
RESULTS: No complications occurred. Adenomyosis was diagnosed in 8 of the 42 subjects with menstrual pain and 5 of the 30 asymptomatic ones (19% versus 17%) and pelvic endometriosis in 27 and 10, respectively (64% versus 33%, P = .02). The frequency of moderate or severe dysmenorrhea was greater in women with adenomyosis than in those without adenomyosis or endometriosis, but the difference was not statistically significant. Conversely, menstrual pain was significantly more frequent and severe in patients with endometriosis as compared with women who had neither endometriosis nor adenomyosis.
CONCLUSION: Uterine needle biopsy is simple, rapid and safe, but its overall clinical importance, as well as the predictive value of a normal histologic result, requires further investigation.
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Cited by (22)
- Classifications of Adenomyosis and Correlation of Phenotypes in Imaging and Histopathology to Clinical Outcomes: a Review 2022
- Exploring the challenges for a new classification of adenomyosis 2020
- Differential diagnosis of adenomyosis: the role of hysteroscopy and laparoscopy 2019
- Classification and Reporting Systems for Adenomyosis 2019
- A Systematic Review of Tissue Sampling Techniques for the Diagnosis of Adenomyosis 2019
- [Endometriosis : An often unrecognized pain disorder] 2016
- Endometriose: Pathogenese, Symptome und Diagnostik 2015
- Accuracy of Hysteroscopic Endomyometrial Biopsy in Diagnosis of Adenomyosis 2015
- The nuclear factor-kB functional promoter polymorphism is associated with endometriosis and infertility 2012
- [Analysis of codon 72 polymorphism of the TP53 gene in infertile women with and without endometriosis] 2011
- PTPN22 C1858T polymorphism in women with endometriosis 2010
- Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values 2009
- OC-125 immunostaining in endometriotic lesion samples 2009
- Adenomyosis and 'endometrial-subendometrial myometrium unit disruption disease' are two different entities 2008
- Adenomyosis 2007
- Adenomyosis: epidemiological factors 2006
- Office hysteroscopy and adenomyosis 2006
- Endokrine operative Therapie der Adenomyosis 2004
- Laparoscopic fertility-pressrving surgery for patients with uterine adenomyosis 2003
- Uterine adenomyosis in the infertility clinic 2003
- Hysteroscopic myometrial biopsy in unexplained abnormal uterine bleeding 1999
- Transvaginal ultrasonography versus uterine needle biopsy in the diagnosis of diffuse adenomyosis 1998
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- europepmc
- last seen: 2026-10-20T06:13:28.455750+00:00
- openalex
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