Effects of photodynamic therapy using 5-aminolevulinic acid on cultured human adenomyosis-derived cells

Haruka Suzuki-Kakisaka, Haruka Suzuki‐Kakisaka, Suzuki-Kakisaka H, Takashi Murakami, Murakami T, Hirano T, Toru Hirano, Tôru Hirano, Terada Y, Yukihiro Terada, Nobuo Yaegashi, Yaegashi N, Kunihiro Okamura, Okamura K
Fertility and sterility · 2006 · vol. 87(1) , pp. 33–38 · doi:10.1016/j.fertnstert.2006.11.066 · PMID:17197284 · W2064485064
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This study investigated the effects of 5-aminolevulinic acid-based photodynamic therapy on cultured human adenomyosis-derived cells, observing its impact on cell viability and proliferation.

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Abstract

OBJECTIVE: To evaluate the potential of photodynamic therapy with aminolevulinic acid (ALA) on human adenomyosis-derived cells compared with endometrial stromal cells. DESIGN: In vitro study. SETTING: Department of Obstetrics and Gynecology, Tohoku University Hospital. PATIENT(S): Women with adenomyosis attending the University hospital. INTERVENTION(S): Photodynamic treatment. MAIN OUTCOME MEASURE(S): Cell survival rates. RESULT(S): Treatment with both ALA and irradiation caused significantly decreased survival of cells derived from human adenomyosis compared with ALA or irradiation alone. The combination of irradiation and ALA led to 79.3%, 68.0%, and 59.5% cell survival at 1.6, 4, and 8 J/cm2, respectively, whereas ALA and irradiation alone caused 92.8% and 97% survival, respectively. CONCLUSION(S): Photodynamic therapy using ALA caused extensive death of cells derived from human adenomyosis. Photodynamic treatment using ALA may be a new treatment for patients with adenomyosis uteri in the future.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Aminolevulinic Acid Endometriosis Endometriosis Endometrium Endometrium Photochemotherapy Adult Adult Aminolevulinic Acid Aminolevulinic Acid Cells, Cultured Cells, Cultured Cell Survival Cell Survival Cell Survival Dose-Response Relationship, Drug Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Dose-Response Relationship, Radiation Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (32)

Cited by (3)

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