Insertion of the Mirena intrauterine system for treatment of adenomyosis-associated menorrhagia: a novel method
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⤵ 16 in-corpus citations
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Yang's insertion method for the Mirena intrauterine system reduced expulsion rates in patients with adenomyosis-associated menorrhagia compared to the conventional method.
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Abstract
OBJECTIVE: Insertion of the levonorgestrel-releasing intrauterine system Mirena is difficult in women with adenomyosis, and the device is often subsequently expelled. We used a novel insertion technique (Yang's method) to overcome this problem.
MATERIALS AND METHODS: This retrospective study enrolled 273 patients with adenomyosis who were receiving Mirena for treatment of menorrhagia and/or dysmenorrhea between 2001 and 2008. Clinical outcomes and expulsion rates were compared between patients treated using conventional insertion and those treated using Yang's insertion methods.
RESULTS: Expulsion occurred in 25.3% of patients with the conventional method, compared with 10.2% of patients with Yang's method. Hemoglobin levels and dysmenorrhea improved greatly in both groups after Mirena insertion.
CONCLUSION: Yang's insertion method for levonorgestrel-releasing intrauterine system is more reliable in some difficult cases, such as patients with severe adenomyosis. This method ensures correct positioning, thus reducing the risks of uterine perforation and/or expulsion.
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References (16)
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Cited by (15)
- Risk factors and countermeasures for abnormal uterine bleeding during dienogest therapy for adenomyosis: a review 2025
- Efficacy of levonorgestrel releasing intrauterine system in the treatment of symptomatic adenomyosis: comparison with dienogest 2025
- Progressively optimized fixation method for levonorgestrel-releasing intrauterine device 2025
- The suture fixation of the levonorgestrel-releasing intrauterine device with hysteroscope for the treatment of adenomyosis in patients at high risk of device expulsion 2024
- Clinical Efficacy of Levonorgestrel Releasing Intrauterine System versus Dienogest for Women having Symptomatic Adenomyosis 2023
- Suture fixation of the levonorgestrel-releasing intrauterine device with hysteroscope for the treatment of adenomyosis in patients at high risk of device expulsion 2023
- Dienogest-based hormonal contraception induced changes in the ultrasound presentation of the uterus and menstrual pain 2021
- Effect of pretreatment with a levonorgestrel-releasing intrauterine system on IVF and vitrified-warmed embryo transfer outcomes in women with adenomyosis 2019
- Long-term dienogest administration in patients with symptomatic adenomyosis 2018
- THE CLINICAL EFFICACY OF SEQUENTIAL USE OF GONADOTROPIN-RELEASING HORMONE ANALOG - LEVONORGESTREL-RELEASING INTRAUTERINE SYSTEM IN MEDICALLY ILL WOMEN WITH SYMPTOMATIC AND RELATIVELY LARGE ADENOMYOSIS 2018
- Adenomiosis: tratamiento 2015
- Levonorgestrel-releasing intrauterine device used for dysmenorrhea: five-year literature review 2014
- Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study 2014
- Effects of levonorgestrel-releasing intrauterine system and T380A intrauterine copper device on dysmenorrhea and days of bleeding in women with and without adenomyosis 2012
- Malpositioned intrauterine contraceptive devices: risk factors, outcomes, and future pregnancies 2011
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- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:07:58.051504+00:00
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