Deciphering biomarkers of endometriosis by proteomic analysis of eutopic endometrium in infertile patients

Zhina Yao, Yao Z, Yousheng Zhang, Zhang Y, Yan J, Junhao Yan, Yan L, Lei Yan
Journal of gynecology obstetrics and human reproduction · 2020 · vol. 50(5) , pp. 102043 · doi:10.1016/j.jogoh.2020.102043 · PMID:33310135 · W3111605538
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Proteomic analysis of eutopic endometrium from infertile patients identified distinct protein profiles that may serve as biomarkers for endometriosis.

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Abstract

AimEndometriosis is associated with infertility. The aim of this study was to examine the overall proteomic changes of eutopic endometrium in infertile women with endometriosis.MethodsTandem mass tags combined with multidimensional liquid chromatography and mass spectrometry analyses were used to screen the proteomic profiles of eutopic endometrium from infertile patients with endometriosis (N = 4), compared with that from patients without endometriosis (N = 4). Quantitative proteomic analysis, functional categories and significant pathway analysis were investigated subsequently.ResultsIn total, 6.698 proteins were identified, among which 5,812 proteins were quantified. Compared with controls, proteomic analysis showed some differentially expressed proteins: 16 up-regulated proteins and 23 down-regulated proteins. Bioinformatics analysis indicated that differentially expressed proteins were involved in humoral immune response pathways, antimicrobial humoral response and regulation of nitric oxide biosynthetic process. Besides, our results showed that alpha-1-acid glycoprotein 2, complement factor B and zinc transporter Zip14 were important resources for investigating potential mechanism of infertility in infertile women with endometriosis.ConclusionsThis study provided a reference proteome map of eutopic endometrium from infertile women with endometriosis. The long-term benefits of using those markers to stratify clinical treatment warrant further investigation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Infertility, Female Proteomics Adult Biomarkers Biomarkers Cation Transport Proteins Cation Transport Proteins Chromatography, Liquid Complement Factor B Complement Factor B Down-Regulation Endometriosis Endometriosis Endometrium Female Humans Infertility, Female Infertility, Female

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