Defective endometrial receptivity represents an important factor in recurrent implantation failure (RIF), though its precise regulatory mechanisms remain unclear. While nicotinamide N-methyltransferase (NNMT) is abundantly expressed in huma…
Abstract Research Question:Does high gonadotropin dosage affect perinatal outcomes of preterm birth (PTB) and low birth weight (LBW) in singletons born after fresh embryo transfer (ET) cycles? Design: This retrospective cohort study includ…
BackgroundThe association of dyslipidemia with embryo development and pregnancy outcomes is largely unknown, especially in unexplained recurrent implantation failure (uRIF) patients. Here, this study aimed to explore the impact of abnormal …
Study questionCan whole exome sequencing (WES) followed by trio bioinformatics analysis identify novel pathogenic genetic causes of first trimester euploid miscarriage?Summary answerWe identified genetic variants in six candidate genes that…
Abstract Problem: Does sildenafil have an effect on pregnancy outcomes in patients with poor endometrial development?Methods: This study included 472 infertility patients who underwent in vitro fertilization/intracytoplasmatic sperm inject…
AimEndometriosis is associated with infertility. The aim of this study was to examine the overall proteomic changes of eutopic endometrium in infertile women with endometriosis.MethodsTandem mass tags combined with multidimensional liquid c…
PurposeTo evaluate whether miR-148a-3p overexpression is associated with disrupted decidualization of recurrent implantation failure (RIF).MethodsEndometrial miRNA and mRNA expression profiles during the implantation window derived from wom…