Peritoneal fluid concentrations of interleukin-4 in relation to the presence of endometriosis, its stage and the phase of the menstrual cycle

M.Rafet Gazvani, Michelle Bates, Gillian Vince, Stephen E. Christmas, D. I. Lewis‐Jones, Charles Kingsland
In: Acta Obstetricia et Gynecologica Scandinavica · 2001 · vol. 80(4) , pp. 361 · doi:10.1080/j.1600-0412.2001.080004361.x · W4247295576
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This study measured peritoneal fluid interleukin-4 concentrations to investigate its association with the presence, stage, and menstrual cycle phase of endometriosis.

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Abstract

BackgroundInterleukin-4 (IL-4) is a cytokine with both stimulatory and inhibitory effects on the inflammatory system such as macrophage inhibition and T-cell activation. It is known to regulate several monocyte functions, including inhibition of the synthesis of cytokines such as IL-1, IL-6 and TNF-alpha as well as potentiating IL-8.MethodIn an attempt to clarify the association between IL-4 and endometriosis, we measured the concentration of IL-4 in the peritoneal fluid of 52 women; 24 with endometriosis and 28 with no endometriosis, controlling for the phase of the cycle and the stage of disease.ResultsThere was no difference in the concentrations of IL-4 between women with (n=28) and without endometriosis (n=24). No difference was found between the IL-4 concentrations in women with different stages of endometriosis. Levels of IL-4 did not show a difference according to the phase of the cycle in either group.ConclusionOur results indicate no association between peritoneal fluid levels of IL-4 and endometriosis and hence suggest that IL-4 is not involved in the pathogenesis of endometriosis.

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endometriosis

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