Pain sensitivity questionnaire in endometriosis

Avonae Gentles, Avonae J Gentles, Sarah Wong, Wong S, Orr NL, Natasha L. Orr, Heather Noga, Noga H, Allaire C, Catherine Allaire, Christina Williams, Williams C, Mohamed A. Bedaiwy, Lee C, Caroline Lee, John R. Kramer, Kramer J, John Kramer, Paul J. Yong
The journal of pain · 2025 · vol. 30 , pp. 105357 · doi:10.1016/j.jpain.2025.105357 · PMID:40049377 · W4408163951
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This paper developed and validated the Pain Sensitivity Questionnaire (PSQ) to assess patients' sensitivity to pain in the context of endometriosis.

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Abstract

There is increasing recognition that nociplastic pain and central sensitization may play a role in endometriosis-associated pain. The Pain Sensitivity Questionnaire Minor (PSQ-M) evaluates subjective widespread pain sensitivity, and is linked to pain outcomes in chronic pain populations. However, evidence connecting the PSQ-M to central sensitization in endometriosis is limited. Using the Central Sensitization Inventory (CSI) as a comparison, this study compared the PSQ-M as a clinical proxy for central sensitization in endometriosis individuals. Data collected from 983 endometriosis participants (mean age of 34 years), between January 2020 and December 2022, were analyzed from a prospective registry. A significant but weak positive correlation was observed between PSQ-M and CSI scores (r=0.099, p<0.001). A significant but weak correlation was found between the number of central sensitivity syndromes and pelvic pain-related comorbidities with the PSQ-M (r=0.093, p<0.001), compared to a stronger correlation with the CSI (r=0.687, p<0.05). PSQ-M scores were not significantly associated with baseline (r=0.013, p=0.797) or post-operative (r=-0.046, p=0.801) quality-of-life. There was no change in the PSQ-M and a small change in CSI after endometriosis surgery, suggesting that surgical treatment of endometriosis does not directly address central sensitization. In conclusion, the PSQ-M may not be the optimal clinical proxy for central sensitization in endometriosis. PERSPECTIVE: This study evaluates the Pain Sensitivity Questionnaire - Minor (PSQ-M) as a proxy for central sensitization in endometriosis. The PSQ-M showed weak correlations with central sensitivity syndromes and pain scores and was not associated with post-surgical quality-of-life, suggesting it may not be the optimal tool for assessing central sensitization in endometriosis.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization Central Nervous System Sensitization

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (65)

Cited by (2)

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