Aromatase inhibitors: potential reproductive implications

Mohamed A. Bedaiwy, Noha A. Mousa, Casper RF, Robert F. Casper
Journal of Minimally Invasive Gynecology · 2009 · vol. 16(5) , pp. 533–539 · doi:10.1016/j.jmig.2009.05.009 · PMID:19608462 · W2019619951
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This paper reviews the potential reproductive consequences of aromatase inhibitors, drugs that block estrogen production.

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Abstract

MEDLINE, EMBASE, Scopus, and Web of Science databases literature search from inception to March 2009 was performed to identify published clinical trials and cohort, observational, and in vitro studies that evaluated the use of aromatase inhibitors in reproductive medicine for indications other than ovulation induction. Aromatase inhibitors are currently being investigated for breast cancer prevention in women at high risk. Aromatase inhibitors may be used for treatment of symptomatic myomas and endometriosis as an alternative to surgical intervention. Current evidence does not support the routine use of aromatase inhibitors for these conditions without prospective controlled trials. Aromatase inhibitor cotreatment can be used to prevent the initial estrogen flare effect of gonadotropin-releasing hormone agonist treatment to offer flexibility in initiating this therapy.

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MeSH descriptors

Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Breast Neoplasms Breast Neoplasms Breast Neoplasms Breast Neoplasms Combined Modality Therapy Combined Modality Therapy Estrogens Estrogens Estrogens Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Humans

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