Increased expression of antimüllerian hormone and its receptor in endometriosis

Patrizia Carrarelli, Carrarelli P, Ana Luiza Lunardi Rocha, Giuseppe Belmonte, Belmonte G, Errico Zupi, Abrão MS, Mauricio Simoẽs Abrão, Maurício Simões Abrão, Felice Arcuri, Arcuri F, Piomboni P, Paola Piomboni, Felice Petraglia
Fertility and sterility · 2014 · vol. 101(5) , pp. 1353–1358 · doi:10.1016/j.fertnstert.2014.01.052 · PMID:24613539 · W1968218850
Other OA: bronze CC0 ⤵ 20 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper reports that the expression of antimüllerian hormone and its receptor is elevated in endometriosis tissue.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To evaluate antimüllerian hormone (AMH) and AMH receptor II (AMHRII) mRNA and protein expression in endometrium and in ovarian or deep lesions of women with endometriosis. DESIGN: Prospective study. SETTING: University hospitals in Italy and Brazil. PATIENTS: Patients with endometriosis (n = 55) and healthy women (n = 45). INTERVENTIONS: Specimens of endometrium obtained by hysteroscopy from patients with endometriosis and from healthy control subjects; specimens of ovarian endometriosis (n = 29) or of deep endometriosis (n = 26) were collected by laparoscopy. Serum samples were collected in some endometriotic patients (n = 23) and healthy control subjects (n = 20). MAIN OUTCOME MEASURE(S): AMH and AMHRII mRNA levels were evaluated by quantitative reverse-transcription polymerase chain reaction and protein localization by immunohistochemistry. AMH levels in tissue homogenates and in serum were assessed by ELISA. RESULT(S): Endometrium from women with endometriosis showed higher AMH and AMHRII mRNA levels than control women, with no significant differences between proliferative and secretory phases. Specimens collected from ovarian or deep endometriosis showed the highest AMH and AMHRII mRNA expression. Immunolocalization study confirmed the high AMH and AMHRII protein expression in endometriotic lesions. No difference of serum AMH levels between the groups was found. CONCLUSION(S): The increased AMH and AMHRII mRNA and protein expression in endometrium and in endometriotic lesions suggests a possible involvement of AMH in endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Endometriosis Gene Expression Regulation Gene Expression Regulation Receptors, Peptide Receptors, Transforming Growth Factor beta Adult Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Anti-Mullerian Hormone Biomarkers Biomarkers Biomarkers Biomarkers Endometriosis Endometriosis Endometriosis Endometrium

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (38)

Cited by (21)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:13:21.326790+00:00
License: CC0 · commercial use OK