Histocompatibility leukocyte antigen-G is not expressed by endometriosis or endometrial tissue

Daniela Hornung, D Hornung, Hornung D, E Fujii, Eriko Fujii, Fujii E, K H Lim, Kee-Hak Lim, Lim KH, Vigne JL, Jean‐Louis Vigne, J L Vigne, M T McMaster, McMaster MT, Michael McMaster, Robert N. Taylor, R N Taylor, Taylor RN
Fertility and sterility · 2001 · vol. 75(4) , pp. 814–817 · doi:10.1016/s0015-0282(00)01791-x · PMID:11287041 · W2122869695
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This study investigated the expression of histocompatibility leukocyte antigen-G (HLA-G) in endometriosis and normal endometrial tissue and found no detectable expression in either.

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Abstract

ObjectiveThe immunological mechanisms that support persistence and proliferation of ectopic endometrial implants within the peritoneal cavity of women with endometriosis are unknown. Inhibition of natural killer (NK) and cytotoxic T-cell function has been proposed as a mechanism. We tested the hypothesis that expression of a nonclassical major histocompatibility antigen, HLA-G, might explain the local immunosuppression associated with ectopic endometrium.DesignNested case-control study of women with and without laparoscopic evidence of endometriosis.SettingReproductive endocrinology clinic at a university hospital.Patient(s)Peritoneal fluid specimens from 10 women with revised AFS stage I-IV endometriosis and from 10 age-matched normal controls without laparoscopic evidence of endometriosis were tested for the presence of HLA-G protein. Endometriosis and normal endometrial biopsies from four patients were used to prepare stromal cell cultures directly evaluated for HLA-G protein.Intervention(s)None.Main outcome measure(s)The expression of HLA-G in peritoneal fluid, tissue, and cell cultures was determined by immunoblotting with a specific monoclonal antibody.Result(s)HLA-G protein was not detectable in peritoneal fluid specimens of endometriosis patients or controls. Moreover, ectopic and normal endometrial tissues and stromal cells did not express HLA-G.Conclusion(s)Immune cell inhibition in endometriosis must be mediated by factors other than HLA-G.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Histocompatibility Antigens Class I HLA Antigens Amino Acid Sequence Antibodies, Monoclonal Ascitic Fluid Ascitic Fluid Blotting, Western Case-Control Studies Cells, Cultured Choriocarcinoma Choriocarcinoma Endometriosis Endometriosis Endometrium Endometrium Endometrium Epitopes Epitopes

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (23)

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