Molecular analysis of clonality in ovarian endometrial cysts

T Yano, Tetsu Yano, Yano T, Haruko Jimbo, H Jimbo, Jimbo H, Yoshikawa H, H Yoshikawa, Hiroyuki Yoshikawa, Tsutsumi O, O Tsutsumi, Osamu Tsutsumi, Yuji Taketani, Taketani Y, Y. Taketani
Gynecologic and obstetric investigation · 1999 · vol. 47(Suppl. 1) , pp. 41–46 · doi:10.1159/000052858 · PMID:10087427 · W2000562460
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This study analyzed X chromosome-linked androgen receptor gene methylation in ovarian endometrial cysts and found all samples were monoclonal, indicating monoclonal origin and potential neoplastic development.

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Abstract

Ovarian endometrial cysts, one of the typical manifestations of endometriosis, are classified as tumor-like lesions rather than as neoplasms. Clonality analysis provides important information on the histogenesis and progression of neoplastic diseases. It is generally accepted that most neoplasms are monoclonal in origin, while the clonality of endometrial cysts remains uncertain. In our study, the clonality of endometrial cysts was analyzed by means of polymerase chain reaction (PCR) based on restriction fragment length polymorphism of the X chromosome-linked human androgen receptor gene (HUMARA) and on random inactivation of the gene by methylation. We separated 21 fresh epithelial cell samples from 11 endometrial cysts and found that all were monoclonal in the methylation pattern of the human androgen receptor alleles. Moreover, in each of the five cysts where epithelial cells were sampled from multiple areas, the methylation patterns of all samples from a single cyst were identical. These data indicate that endometrial cysts are monoclonal in origin and suggest their neoplastic potential.

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Condition tags

endometriosis

MeSH descriptors

Clone Cells Endometrium Ovarian Cysts Ovarian Cysts Adult Adult Alleles Alleles Cell Separation Cell Separation Clone Cells Clone Cells Clone Cells DNA DNA DNA Dosage Compensation, Genetic Dosage Compensation, Genetic Endometriosis Endometriosis

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