Serum CA125 as a biomarker for dysmenorrhea in adenomyosis

Tang Y, Ying Tang, Wen MB, Ming-Bo Wen, Ming‐bo Wen, Rumei Xiang, Ru-Mei Xiang, Ming‐Tao Yang, Ming-Tao Yang, Yang MT, Bin Shu, Shu B, Xu F, Fan Xu, Jun Li, Li J, Hui-Quan Hu, Huiquan Hu, Hu HQ, Shi Q, Qiuling Shi
International Journal of Gynecology & Obstetrics · 2023 · vol. 163(1) , pp. 131–139 · doi:10.1002/ijgo.14832 · PMID:37177806 · W4376505055
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Serum CA125 levels are elevated in adenomyosis patients experiencing dysmenorrhea, with a cut-point of 35 U/mL identifying dysmenorrhea and correlating positively with lesion volume and negatively with age.

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Abstract

OBJECTIVE: To explore the association between CA125 and dysmenorrhea in adenomyosis, and the factors affecting CA125 in adenomyosis. METHODS: Patients were grouped a the presence of dysmenorrhea. The receiver operating characteristic (ROC) curve was applied to assess the utility of CA125 for dysmenorrhea. Binary logistic regression was employed to identify the factors associating dysmenorrhea and CA125 level. RESULTS: Patients in the dysmenorrhea group had higher CA125 levels than those in the non-dysmenorrhea group. For those with dysmenorrhea, CA125 levels of diffuse subtype group were higher than those of the focal subtype group. The CA125 level of 35 U/mL was validated as the optimal cut-point for dysmenorrhea in ROC curves. Compared with patients whose CA125 was 35 U/mL or less, those with CA125 levels greater than 35 U/mL were more likely to have dysmenorrhea. Thereafter, the multiple regression analysis showed that adenomyotic lesion volume was positively correlated with CA125 level in the total cohort and subtype groups, while age was negatively correlated with CA125 level in the total cohort and diffuse subtype. CONCLUSIONS: The pathogenesis of adenomyosis is not clear. CA125 was associated with dysmenorrhea in adenomyosis, and, furthermore, CA125 level is positively correlated with the severity of the disease.

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Condition tags

dysmenorrheaadenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (34)

Cited by (15)

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