Cytotoxic T Lymphocytes, Tc17 Cells, Th1 Cells, and ThGM Cells are Increased in the Blood and Ectopic Endometrium of Patients With Adenomyosis

Li Zhang, Lei Zhu, Pengfei Che, Xiaoyan Sun, Yupeng Guo, Mingjie Gao, Junjie Wang
American journal of reproductive immunology (New York, N.Y. : 1989) · 2024 · vol. 92(1) , pp. e13901 · doi:10.1111/aji.13901 · PMID:39042523 · W4400913085
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Cytotoxic T lymphocytes, Tc17 cells, Th1 cells, and ThGM cells are increased in the blood and ectopic endometrium of patients with adenomyosis, with levels normalizing after focused ultrasound ablation surgery.

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Abstract

ABSTRACT Problem Adenomyosis (AM) is associated with immune response and inflammation. However, the role of T cell subsets in AM development has not been thoroughly understood. Method of Study Patients with focal or diffuse AM were recruited. Serum cytokines were quantified by enzyme‐linked immunosorbent assay (ELISA). Different T cell subsets in the blood and ectopic endometrium were determined by flow cytometry. Results Serum interleukin‐6 (IL‐6) and macrophage‐colony‐stimulating factor (GM‐CSF) were increased in patients with focal or diffuse AM before focused ultrasound ablation surgery (FUAS), but not after FUAS. Compared with the healthy control, the frequencies of CD8 + interferon‐gamma (IFN‐γ)‐expressing cytotoxic T lymphocytes (CTLs), interleukin‐17A (IL‐17A)‐expressing Tc17 cells, CD4 + T helper 1 (Th1) cells, and GM‐CSF‐expressing T helper (ThGM) cells were up‐regulated in the blood of patients with AM, especially those with diffuse AM. However, these changes were eradicated after FUAS. Meanwhile, the frequencies of these T cell subsets were positively correlated with the CA‐125 level. Furthermore, these T cell subsets were also increased in ectopic endometrium. Conclusions Our study delineates for the first time the presence of CTLs, Tc17 cells, Th1, and ThGM cells in the blood and ectopic endometrium in AM. The results imply that T cell response might impact AM development.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

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