Endometriosis: in search of optimal treatment

Nothnick WB, W B Nothnick
Minerva ginecologica · 2010 · vol. 62(1) , pp. 17–31 · PMID:20186112 · W111506442
Review OA: closed CC0 ⤵ 14 in-corpus citations
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This review discusses current hypoestrogenic treatments for endometriosis, their side effects and limitations, and explores potential alternative therapies like aromatase inhibitors and angiogenesis disruptors.

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Abstract

Endometriosis is an enigmatic, debilitating disease which affects as many as 15% of all women of reproductive age and is characterized by pelvic pain and infertility. Current treatment regimes used to manage the disease do so by inducing a hypoestrogenic state. While the absence of circulating estrogen levels lead to a regression of the disease, this hypoestrogenism also induces many unpleasant and unwanted side-effects. As such, these and other shortcomings of current drug therapies emphasize their limitations and the necessity for the development of novel endometriosis treatments. In this review, current therapies for medical management of endometriosis are discussed as are their shortcomings. Potential target areas which may be attractive alternatives to current therapies are also reviewed and include aromatase inhibitors, angiogenesis disruptors and anti-tumor necrosis factor-alpha inhibitors.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Adalimumab Adalimumab Anastrozole Anastrozole Angiogenesis Inhibitors Angiogenesis Inhibitors Angiogenesis Inhibitors Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Antibodies, Monoclonal, Humanized Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (14)

SciLite annotations

chemicals 1
estrogen

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License: CC0 · commercial use OK