Complex therapy of external genital endometriosis with immunomodylators

В. М. Запорожан, Валентина Васильевна Евдокимова
In: Reproductive Endocrinology · 2012 · vol. 0(8) , pp. 6 · doi:10.18370/2309-4117.2012.8.6-9 · W1483435587
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Combined hormone therapy with the immunomodulator Immunomax reduced TNF-α, IL-6, and IL-8 levels and prevented endometriosis recurrence by normalizing immunograms.

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This study investigated the effects of combining hormone therapy with immunomodulators, specifically Immunomax, on patients with external genital endometriosis. The researchers measured cytokine production levels and found that while baseline levels remained stable after one month, combined treatment significantly reduced TNF-α and IL-6 by 21% and decreased IL-8 threefold. Clinical outcomes indicated that using these immunomodulators normalized immunogram indicators and prevented disease recurrence in the comparison groups. This paper is centrally about endometriosis — specifically evaluating adjunctive immunotherapy for external genital lesions to improve prognosis and reduce relapse rates.

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Abstract

In the study of cytokine production in patients with endometriosis after 1 month the cytokine production levels did not change significantly. The level of TNF-α and IL-6 in these patients after combined treatment (hormone therapy) decreased by 21% and IL-8 to 3 times. There was not recurrence of the disease after using immunomodulators in the comparison groups. The use of natural low molecular weight immunomodulator Immunomax in the treatment of endometriosis normalized indicators of immunograms. Combined therapy with the use of immunomodulators improved prognosis and prevent endometriosis recurrence.
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Complex therapy of external genital endometriosis with immunomodylators DOI: https://doi.org/10.18370/2309-4117.2012.8.6-9Keywords: endometrіosis, adenomіosis, іmomodulator therapy, cytokіnes, toumor necrosis factorAbstract In the study of cytokine production in patients with endometriosis after 1 month the cytokine production levels did not change significantly. The level of TNF-α and IL-6 in these patients after combined treatment (hormone therapy) decreased by 21% and IL-8 to 3 times. There was not recurrence of the disease after using immunomodulators in the comparison groups. The use of natural low molecular weight immunomodulator Immunomax in the treatment of endometriosis normalized indicators of immunograms. Combined therapy with the use of immunomodulators improved prognosis and prevent endometriosis recurrence. References - Баскаков В.П. Эндометриоидная болезнь / В.П. Баскаков, Ю.В. Цвелев, Е.В. Кира. – СПб., 2002. – 452 с. - Євдокимова В.В. Імунологічне дослідження крові пацієнток, хворих на ендометріоз. Сучасні принципи лікування генітального ендометріозу імуномодуляторами / В.В. Євдокимова // Практична медицина. – 2011. – Вип. 4. – Т. XVII. – С. 67-78. - Евдокимова В.В. Современные принципы лечения наружного генитального эндометриоза и восстановление фертильности. Показатели иммунологического состояния и цитокинового профиля крови / В.В. Евдокимова // Вісник морської медицини. – 2012. – № 2 (56). – С. 60-66. - Ищенко А.И. Эндометриоз. Диагностика и лечение. / А.И. Ищенко, Е.А. Кудрина. – М.: ГЭОТАР-МЕД, 2002. – 115 с. - Крамарева Н.Л. Значение компонентов иммунной системы и генетических факторов в патогенезе и терапии наружного генитального эндометриоза. Автореферат дисс. на соиск. уч. ст. канд. мед. наук. – СПб, 2002. – 24 с. - Линде В.А. Иммунологические аспекты эндометриозов (обзор литературы) / В.А. Линде, Н.А. Татарова, О.И. Гришанина // Проблемы репродукции. – 2008. – № 4. – С. 74-77. - Малашенкова И.К. К вопросу о значении индивидуального подбора иммунокорректоров / И.К. Малашенкова, Н.А. Дидковскип, А.А. Левко // Фарматека. – 2004. –№ 12. – С. 26-33. - Dmowski P.W. Immunology of endometriosis. / P.W. Dmowsli, D.P. Braun // Best Pract Res Clin Obstet Gynaecol. – 2004 – Vol. 18 (2) – P. 245-26. - Guidice L.C., Evers J.L., Healy D.L., WИЛey-Blackwell NY. Endometriosis: Science and Practice / 1 ed. – 2012. – 552 p. - Nothnick W.B. Endometriosis: in search of optimal treatment / W.B. Nothnick // Minerva Ginecol. – 2010. – Vol. 62 (1) – P. 17-31. - Laschke M.W. Anti-angiogenic treatment strategies for the therapy of endometriosis / M.W. Laschke, M.D. Menger // Hum Reprod Update. – 2012. – Vol. 18 (6) – P. 682-702. Downloads Published How to Cite Issue Section License Copyright (c) 2014 В. М. Запорожан, В. В. Евдокимова This work is licensed under a Creative Commons Attribution 4.0 International License. Authors who publish with this journal agree to the following terms: - Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. - Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

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