Aspects of inhibition of myometrial hyperactivity in primary dysmenorrhea

A Forman, Axel Forman, U. Ulmsten, K.‐E. Anderson, K E Andersson
Acta obstetricia et gynecologica Scandinavica. Supplement · 1983 · vol. 62(s113) , pp. 71–76 · doi:10.3109/00016348309155202 · PMID:6134424 · W2153640538
Review OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-29 ⓘ

This paper reviews mechanisms controlling myometrial calcium concentration and discusses how prostaglandin synthesis inhibitors, calcium antagonists, and beta 2 stimulators reduce uterine hyperactivity and dysmenorrheic pain.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Uterine hypercontractility is considered to be an important factor in primary dysmenorrhea. A survey is given on possible mechanisms controlling the cytoplasmic concentration of free calcium and thereby contractile activity in the myometrial smooth muscle cell. Probably acting by different modes of action, inhibitors of prostaglandin synthesis, calcium antagonists and beta 2 stimulators have all been shown to reduce myometrial activity and relieve dysmenorrheic pain. The possibility of achieving further uterine relaxation after initial treatment with prostaglandin inhibitors by adding a calcium antagonist such as nifedipine is discussed. It is also suggested that when utilizing a reliable pressure recording technique in the evaluation of dysmenorrheic patients, the pronounced myometrial relaxation obtained by such combined therapy may be of diagnostic value.

My notes (saved in your browser only)

Condition tags

dysmenorrhea

MeSH descriptors

Dysmenorrhea Myometrium Uterus Adrenergic beta-Agonists Adrenergic beta-Agonists Calcium Calcium Calcium Channel Blockers Calcium Channel Blockers Cyclooxygenase Inhibitors Dysmenorrhea Dysmenorrhea Dysmenorrhea Female Humans Ion Channels Ion Channels Muscle Contraction Muscle Contraction Muscle, Smooth

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (44)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:58:02.984372+00:00
unpaywall
last seen: 2026-10-19T06:34:38.229974+00:00
License: CC0 · commercial use OK