Immunological and endocrinological studies on lymphocyte subpopulation and medical treatment for infertility in patients with endometriosis

Kenichi Furuya, Furuya K, Murakami M, Mitsutaka Murakami, N. Makimura, Makimura N, Noriko Makimura, Hideo Matsuda, Matsuda H, Kanoko Ikou, Ikou K, Keiko Saito, Saito K, Kawakami Y, Yuichi Kawakami, Shibazaki T, Tomoko Shibazaki, Fukui U, Utako Fukui, Yoshifumi Mizumoto, Mizumoto Y, Susumu Tokuoka, Tokuoka S, Nagata I, Ichiro Nagata, Yoshihiro Kikuchi, Kikuchi Y
Molecular and cellular endocrinology · 2003 · vol. 202(1-2) , pp. 195–199 · doi:10.1016/s0303-7207(03)00083-2 · PMID:12770751 · W1995551209
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This study investigated the immunological and endocrinological profiles of lymphocyte subpopulations in infertile patients with endometriosis and examined the effects of medical treatments.

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Abstract

We investigated the relationship between interleukin-6 (IL-6) levels and subset profiles of T lymphocyte (T-cell) and macrophage in peritoneal fluid (PF) with or without endometriosis (EM). IL-6 levels in PF with EM were significantly higher than those without EM. IL-6 producing cells with EM were analyzed in each activated mature T-cell (CD3+CD69+) and macrophage (CD14+) were 0.5 and 3.5%, respectively, whereas it was mostly negative in those without EM. Cytotoxic T-cell (CD8+CD11b-) profiles in PF with EM were also quiet different from those without EM. Cellular immunity in the peripheral blood did not change during the course of IVF-ET cycles, although plasma levels of ovarian steroid hormones significantly increased comparing with that in normal ovarian cycles. Cytotoxic T-cell type 1 (Tc1) profiles might be useful predictive values in the pregnancy outcome for infertile patients with EM.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female T-Lymphocyte Subsets Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Cytokines Cytokines Cytokines Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (7)

Cited by (11)

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