Evolution of endometriosis research: A comprehensive analysis of research designs and topics over the last 15 years

Marlene Wettstein, Patrick Imesch, Isabell Witzel, Julian Matthias Metzler
In: Journal of Endometriosis and Uterine Disorders · 2024 · vol. 7 , pp. 100076 · doi:10.1016/j.jeud.2024.100076 · W4393999944
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This review analyzed 2007-2022 endometriosis research, finding an increase in observational and laboratory studies, a decrease in interventional studies and case reports, and a growing need for research in diagnostics, pathophysiology, and treatment.

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Abstract

The aim of this review is to analyse the progression of endometriosis research from 2007 to 2022. The PubMed database was searched for publications with titles containing the keyword endometriosis, being created in January and July of the years 2007, 2012, 2017 and 2022. Each publication was categorized by research design and topic. We defined a total of seven groups containing twenty-three categories. The total number of publications per year increased from 393 in 2007 to 1042 in 2022. Regarding categories, the relative fraction of the Observational Study category increased from 32% to 45%. A similar development can be seen in the Laboratory Study/Experiment category which increased from 4% to 10%. Meanwhile, Interventional Study decreased from 7% to 5%. The relative number of Case Reports dropped from 25% to 13%. The absolute number of every category increased from 2007 to 2022. Concerning topics, the Diagnostics group increased from 10% to 15%. The Pathophysiology group decreased from 63% to 51%. In the Treatment group, a decrease of 33% to 26% was observed. Finally, the Other group saw an increase from 11% to 16%. We saw an increase in the number of publications in several categories. However, we identified a need for more research in the Diagnostics, Pathophysiology and Treatment categories. Overall, we concluded that more basic research and more clinical studies are needed to better understand endometriosis as a disease and to better help affected patients.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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