Studies on the human leukocyte antigen class I antigens in Japanese patients with macroscopically diagnosed endometriosis

Keisuke Ishii, Ishii K, Koichi Takakuwa, Takakuwa K, Adachi H, Hiroshi Adachi, Higashino M, Masahiko Higashino, Isao Hataya, Hataya I, Kenichi Tanaka, Tanaka K
Gynecologic and obstetric investigation · 2002 · vol. 54(3) , pp. 150–153 · doi:10.1159/000067882 · PMID:12571436 · W2014651092
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This study found higher frequencies of HLA-B54 and HLA-Cw7 in Japanese patients with endometriosis compared to controls, suggesting a potential role for these human leukocyte antigens in the disease.

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Abstract

An increasing number of reports suggest that endometriosis is associated with abnormal immune function, although the etiology of the disease remains undefined. The human leukocyte antigen system (HLA) is known to play a role in the etiology of a number of diseases. This study examines the possible association between the HLA system and endometriosis. Fifty-five patients diagnosed with endometriosis by laparoscopic examination were typed for HLA class I antigens - HLA-A, -B, and -C antigens - using the standard microlymphocytotoxity technique of Terasaki. The frequency of HLA-B 54 and that of HLA-Cw7 were significantly higher in the patient population than in the control population. No significant difference was found between the two groups in the frequencies of the other HLA-class I antigens. The results of this study may implicate the HLA system in the development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Histocompatibility Antigens Class I Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Female Female Histocompatibility Antigens Class I Histocompatibility Antigens Class I Histocompatibility Antigens Class I Histocompatibility Testing Histocompatibility Testing HLA-A Antigens HLA-A Antigens HLA-A Antigens HLA-B Antigens

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

Cited by (9)

Source provenance

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