Der Kampf mit der Hydra

In: Der Gynäkologe · 2017 · vol. 50(6) , pp. 428–432 · doi:10.1007/s00129-017-4077-4 · W2619174467
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Surgical excision of minimal and mild endometriosis benefits pregnancy, while ART is more effective than repeated surgery after spontaneous conception fails.

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This paper discusses the contested role and extent of surgical intervention for endometriosis, focusing particularly on cases with bowel (colon and rectum) involvement and how these decisions relate to fertility outcomes. It reports that complete surgical excision/ablation of lesions is beneficial in women with minimal or mild endometriosis, while after failed spontaneous conception following first-line surgery, assisted reproduction techniques (IVF) appear more effective than repeating surgery. It also states that women with large endometriomas should undergo surgery to improve ovarian access for oocyte retrieval and to reduce infection risk, and that when IVF fails despite severe, asymptomatic endometriosis, a personalized treatment strategy is needed, with second-line conservative radical surgery possibly favoring subsequent IVF outcomes. This paper is centrally about endometriosis — it addresses how much surgery to perform, especially for bowel disease, and its implications for fertility/IVF strategies.

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Zusammenfassung Diagnostik und Behandlung der Endometriose ist eine Domäne der gynäkologischen Chirurgie. Hingegen bleibt die Frage nach dem Ausmaß der chirurgischen Intervention, um ein Konzeption zu ermöglichen, kontrovers. Dies gilt insbesondere für die Behandlung bei Befall von Kolon und Rektum. Als eindeutig vorteilhaft hat sich die chirurgische Eradikation von Endometrioseläsionen bei minimaler und milder Endometriose herausgestellt. Bei Ausbleiben einer Spontankonzeption nach kompletter Operation scheint die Anwendung von ART(„assisted reproduction techniques“)-Maßnahmen (In-vitro-Fertilisierung, IVF) Vorteile gegenüber einer erneuten Operation zu haben. Frauen mit großen Endometriomen oder Endometriosezysten sollten chirurgisch behandelt werden, allein um die Follikelpunktion zu erleichtern und das Risiko einer Infektion zu minimieren. Kommt es nach mehrfachen IVF-Versuchen nicht zur Schwangerschaft und besteht eine symptomlose, aber schwere und sehr ausgedehnte Endometriose, ist eine individuelle, personalisierte Behandlungsstrategie erforderlich. Eine erneute konservative radikale Operation scheint das nachfolgende IVF-Ergebnis eher zu verbessern. Abstract Surgery remains the mainstay in the diagnosis and management of endometriosis. The extent of surgery to achieve pregnancy in infertile patients with endometriosis is still under debate in particular concerning involvement of the bowel. In women with minimal and mild endometriosis surgical excision or ablation of endometriotic lesions has turned out to be beneficial to reach the goal of pregnancy. In patients who failed to conceive spontaneously after first line surgery, assisted reproduction techniques (ART) seem to be more effective than repeated surgical interventions. Women with larger endometriomas should undergo repeated surgery for better accessibility to the ovaries if it comes to in vitro fertilization (IVF). Infection rate is likely to be reduced after ovum pick-up. In case of failed IVF and severe endometriosis without symptoms a personalized tailored treatment strategy is mandatory probably in favor of second line conservative radical surgery. Similar content being viewed by others Literatur Peirce CL, Templeman C, Rossing MA (2012) On behalf of the ovarian cancer association consortium. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol 13:385–394 Leitlinien Endometriose der DGGG (2013) (S2k): Leitlinien zur Diagnostik und Therapie der Endometriose. 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Küpker, Bühl Rights and permissions About this article Cite this article Agic, A., Küpker, W. Der Kampf mit der Hydra. Gynäkologe 50, 428–432 (2017). https://doi.org/10.1007/s00129-017-4077-4 Published: Issue date: DOI: https://doi.org/10.1007/s00129-017-4077-4

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