Nafarelin therapy in endometriosis: long-term effects on bone mineral density

E S Orwoll, Eric Orwoll, Orwoll ES, A. Albert Yuzpe, A A Yuzpe, Yuzpe AA, Burry KA, K A Burry, Kenneth A. Burry, Heinrichs L, LeRoy Heinrichs, L Heinrichs, Buttram VC Jr, V C Buttram, Veasy C. Buttram, Hornstein MD, M D Hornstein, Mark D. Hornstein
American journal of obstetrics and gynecology · 1994 · vol. 171(5) , pp. 1221–1225 · doi:10.1016/0002-9378(94)90136-8 · PMID:7977523 · W2164254596
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This study investigated the long-term effects of nafarelin therapy on bone mineral density in patients with endometriosis.

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Abstract

OBJECTIVE: The study intent was to examine long-term effects on bone mass of 3 or 6 months of nafarelin therapy for endometriosis. STUDY DESIGN: Women with established endometriosis (N = 173) were randomized to receive nafarelin (200 micrograms intranasally twice a day) for either 3 or 6 months in a double-blind fashion. Bone mineral density was measured by dual energy x-ray absorptiometry at lumbar spine and proximal femoral sites for 18 months. RESULTS: Bone mineral density declined at spinal and femoral sites similarly in both 3- and 6-month treatment groups. There was a partial, but incomplete, return to baseline levels after 12 to 15 months of follow-up. The recovery of bone mass was more complete in subjects with higher dietary calcium intakes. CONCLUSION: Nafarelin therapy for endometriosis results in a sustained loss of spinal and femoral bone density, particularly in women with lower calcium intakes.

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Condition tags

endometriosis

MeSH descriptors

Bone Density Endometriosis Nafarelin Adolescent Adolescent Adult Adult Bone Density Bone Density Double-Blind Method Double-Blind Method Endometriosis Endometriosis Estradiol Estradiol Estradiol Female Female Femur Femur

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

Cited by (25)

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