Therapeutic efficacy and bone mineral density response during and following a three-month re-treatment of endometriosis with nafarelin (Synarel)

G D Adamson, G. David Adamson, Heinrichs WL, W L Heinrichs, M R Henzl, Milan R. Henzl, Henzl Mr, A A Yuzpe, Albert Yuzpe, Yuzpe AA, Christer Bergquist, Bergquist C, C Bergquist, Jacobson JJ, Jan J. Jacobson, J J Jacobson, Eriksson S, S Eriksson, Staffan Eriksson, Kwei L, Long Kwei, L Kwei, Sandra M. Gilbert, S M Gilbert, Gilbert SM
American journal of obstetrics and gynecology · 1997 · vol. 177(6) , pp. 1413–1418 · doi:10.1016/s0002-9378(97)70084-x · PMID:9423744 · W2146137592
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This study investigated the therapeutic effects and bone mineral density changes in endometriosis patients undergoing three months of re-treatment with nafarelin.

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Abstract

ObjectiveOur goal was to determine the effects of a repeated course of the gonadotropin-releasing hormone agonist nafarelin on symptoms and signs of endometriosis and lumbar and distal radius bone mineral density.Study designForty-five women previously treated for 6 months with nafarelin, who had recurrent symptoms and signs of endometriosis, received 400 mcg/day of nafarelin intranasally for 3 months. Efficacy was evaluated by changes in severity of symptoms and signs. Lumbar bone mineral density was measured by dual-energy x-ray absorptiometry and distal radius bone mineral density by single-photon absorptiometry. Bone mineral density was also measured in 10 control volunteers.ResultsRepeated 3-month treatment significantly alleviated recurrent symptoms and signs of endometriosis. Lumbar bone mineral density decreased significantly by a mean of 2% at the end of treatment; this loss was restored within 3 to 6 months after treatment completion. No bone mineral density decline occurred in the radius. Bone mineral density changes in the control group were statistically insignificant.ConclusionsA repeated 3-month course of nafarelin treatment significantly relieved recurrent endometriotic symptoms and signs without sustained loss of bone mineral density.

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Condition tags

endometriosis

MeSH descriptors

Bone Density Endometriosis Endometriosis Hormones Nafarelin Adult Endometriosis Estradiol Estradiol Female Hormones Hormones Humans Menstrual Cycle Menstrual Cycle Middle Aged Nafarelin Nafarelin Recurrence Retreatment

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