Nafarelin therapy in endometriosis: Long-term effects on bone mineral density

E S Orwoll, Eric Orwoll, Orwoll ES, A. Albert Yuzpe, A A Yuzpe, Yuzpe AA, Burry KA, K A Burry, Kenneth A. Burry, Heinrichs L, LeRoy Heinrichs, L Heinrichs, Buttram VC Jr, V C Buttram, Veasy C. Buttram, Hornstein MD, M D Hornstein, Mark D. Hornstein
American journal of obstetrics and gynecology · 1994 · vol. 171(5) , pp. 1221–1225 · doi:10.1016/0002-9378(94)90136-8 · PMID:7977523 · W2164254596
article OA: closed CC0 ⤵ 25 in-corpus citations
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This study investigated the long-term effects of nafarelin therapy on bone mineral density in patients with endometriosis.

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Abstract

ObjectiveThe study intent was to examine long-term effects on bone mass of 3 or 6 months of nafarelin therapy for endometriosis.Study designWomen with established endometriosis (N = 173) were randomized to receive nafarelin (200 micrograms intranasally twice a day) for either 3 or 6 months in a double-blind fashion. Bone mineral density was measured by dual energy x-ray absorptiometry at lumbar spine and proximal femoral sites for 18 months.ResultsBone mineral density declined at spinal and femoral sites similarly in both 3- and 6-month treatment groups. There was a partial, but incomplete, return to baseline levels after 12 to 15 months of follow-up. The recovery of bone mass was more complete in subjects with higher dietary calcium intakes.ConclusionNafarelin therapy for endometriosis results in a sustained loss of spinal and femoral bone density, particularly in women with lower calcium intakes.

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Condition tags

endometriosis

MeSH descriptors

Bone Density Endometriosis Nafarelin Adolescent Adult Bone Density Double-Blind Method Endometriosis Estradiol Estradiol Female Femur Femur Humans Longitudinal Studies Middle Aged Nafarelin Nafarelin Regression Analysis Spine

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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