Gonadotropin-releasing hormone analogs: Update onnew findings
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This paper reviews new findings on gonadotropin-releasing hormone analogs, which are used to treat various hormone-dependent conditions.
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Abstract
Clinical trials are under way to investigate the optimal use of nafarelin. In one series of studies, the effect of nasal mucosal inflammation and the concomitant use of nasal decongestants on the nasal absorption of nafarelin was evaluated in women with perennial rhinitis. Neither rhinitis nor concomitant therapy with a long-acting nasal decongestant substantially affected the nasal absorption of nafarelin. Other clinical studies are investigating strategies for second treatment of endometriosis or to improve the safety profile of nafarelin. In one trial, a second 3-month treatment course with nafarelin in patients with recurrent symptoms of endometriosis provided substantial pain relief. In another trial, preliminary information indicates that the addition of norethindrone to nafarelin in patients with endometriosis attenuates bone density changes and menopausal symptoms associated with nafarelin treatment.
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References (7)
- Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis via openalex
- Effects of progestins on bone metabolism in postmenopausal women. via openalex
- Gonadotropin-Releasing Hormone (GnRH) Agonists in the Management of Endometriosis: A Review via openalex
- Is It Possible to Prevent Bone Loss in Young Women Treated with Luteinizing Hormone-Releasing Hormone Agonists? via openalex
- The effects of combining norethindrone with a gonadotropin-releasing hormone agonist in the treatment of symptomatic endometriosis via openalex
- The effects of combining norethindrone with a gonadotropin‐releasing hormone agonist in the treatment of symptomatic endometriosis via openalex
- W1968675652 via openalex
Cited by (2)
Source provenance
- europepmc
- last seen: 2026-07-28T06:14:09.330459+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:11:49.821429+00:00
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