Polymorphisms of Estrogen Receptor-α and Estrogen Receptor-β Genes and its Expression in Endometriosis

Eldafira Eldafira, Vivitri Dewi Prasasty, A. Abinawanto, Abinawanto Abinawanto, Luthfiralda Syahfirdi, Dwi Ari Pujianto
Turkish journal of pharmaceutical sciences · 2021 · vol. 18(1) , pp. 91–95 · doi:10.4274/tjps.galenos.2019.94914 · PMID:33634683 · PMC7957307 · W3000404822
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Abstract

OBJECTIVES: Endometriosis is a common gynecological disorder, characterized by the presence of endometrial-like tissue in the extrauterine location. The increasing estradiol concentration can influence endometriosis risk and estrogen receptor (ER) activity. Polymorphism in ER causes gene expression alteration and influences hormone-receptor interaction. This research aims to determine ER genetic polymorphisms in endometriosis pathogenesis. MATERIALS AND METHODS: gene expression analysis and estrogen level measurement were obtained from 18 women with endometriosis and 18 women without endometriosis. Polymerase chain reaction-restriction fragment length polymorphism was used to determine ER genetic polymorphisms. Chi-square, Mann-Whitney test, Spearman's correlation (p), t-independent, and two-tailed tests were used to analyze the data. RESULTS: Association between the allele ERα rs9340799 A/G and endometriosis was significantly different (p=0.012), whereas rs2234693 T/C polymorphism showed no association with endometriosis. The correlation between the genotype frequencies of allele ERβ rs4986938 G/A and endometriosis was found significantly different (p=0.015; p=0.034). CONCLUSION: gene have roles in endometriosis.

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endometriosis

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