Analysis of biomarker expression in severe endometriosis and determination of possibilities for targeted intraoperative imaging

Liseth L. van den Berg, van den Berg LL, Crane LM, Lucia M A Crane, van Oosten M, Marleen van Oosten, van Dam GM, Gooitzen M. van Dam, Arnold Simons, Arnold H M Simons, Simons AH, H. Sijbrand Hofker, Hofker HS, Joost Bart
International Journal of Gynecology & Obstetrics · 2013 · vol. 121(1) , pp. 35–40 · doi:10.1016/j.ijgo.2012.10.025 · PMID:23332132 · W2139706470
Other OA: closed CC0 ⤵ 21 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study evaluated seven biomarkers in endometriotic tissue and found EpCAM, FR-α, and VEGF-A to be the most promising for targeted intraoperative imaging.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To evaluate the expression of biomarkers in endometriotic tissue in order to determine the most promising molecules for targeted intraoperative imaging. METHODS: Tissue samples were obtained from 18 patients with endometriosis. The intensity and pattern of expression of the following biomarkers were assessed by immunohistochemistry: C-X-C chemokine receptor type 4 (CXCR4), epithelial cell adhesion molecule (EpCAM), estrogen receptor (ER), folate receptor α (FR-α), hypoxia-inducible factor 1-α (HIF-1α), progesterone receptor (PR), and vascular endothelial growth factor A (VEGF-A). The Target Selection Criteria scoring system was used to select the most promising biomarkers for intraoperative imaging. RESULTS: Expression of CXCR4, EpCAM, ER, PR, and VEGF-A was scored as strong in endometriotic epithelium. Expression of FR-α was detected in 94.4% of samples, whereas HIF-1α was expressed in just 5.6% of samples. Of note, CXCR4, ER, and VEGF-A were also expressed in surrounding healthy tissue, thus reducing the target-to-background ratio. CONCLUSION: Of the 7 biomarkers assessed in the present study, EpCAM, FR-α, and VEGF-A seem the most promising for targeted intraoperative imaging of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Antigens, Neoplasm Cell Adhesion Molecules Endometriosis Folate Receptor 1 Vascular Endothelial Growth Factor A Adult Adult Antigens, Neoplasm Antigens, Neoplasm Biomarkers Biomarkers Biomarkers Cell Adhesion Molecules Cell Adhesion Molecules Endometriosis Endometriosis Epithelial Cell Adhesion Molecule Epithelial Cell Adhesion Molecule Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

Cited by (21)

Source provenance

europepmc
last seen: 2026-10-14T06:08:39.101224+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:11:19.299510+00:00
unpaywall
last seen: 2026-10-13T06:25:51.201866+00:00
License: CC0 · commercial use OK