Regeneration and adult stem cells in the human female reproductive tract

Masanori Ono, Tetsuo Maruyama, Y. Yoshimura
In: Stem Cells and Cloning: Advances and Applications · 2008 · vol. Volume 1 , pp. 23–29 · doi:10.2147/sccaa.s4269 · PMID:24198502 · PMC3781684 · W1960121115
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

The human uterus possesses remarkable regenerative capacity, supported by evidence of endometrial and myometrial stem cell systems crucial for its cyclical remodeling.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This paper is a review discussing how the human uterus shows extensive regenerative capacity through cyclical remodeling during reproductive life, proposing that distinct endometrial and myometrial stem cell systems contribute to regeneration. It summarizes experimental evidence for adult stem cells in the female reproductive tract and frames characterization of these cells and their regulatory mechanisms as key to understanding both physiology and pathophysiology. The article’s main caveat is that, as a narrative review, it does not present new original experimental results or a specific new dataset. Relevance to endometriosis: the paper focuses on endometrial and myometrial stem cells and uterine remodeling, processes closely connected to the endometrial pathology at the core of endometriosis.

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Abstract

Regeneration and adult stem cells in the human female reproductive tract Masanori Ono, Tetsuo Maruyama, Yasunori YoshimuraDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku, Tokyo, JapanAbstract: The human uterus is unique in that it exhibits a tremendous regenerative capacity that enables cyclical regeneration and remodeling throughout a woman’s reproductive life. This plasticity of the reproductive system has recently been highlighted. Regeneration and remodeling in the female reproductive tract alludes to the existence of endometrial and myometrial stem cell systems, which has been supported by increasing experimental evidence. Characterization of these stem cells, along with the study of the mechanisms controlling their regeneration, will improve the understanding of the physiology and pathophysiology of the female reproductive tract.Keywords: adult stem cells, endometrium, myometrium, regeneration

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