Application of autologous adipose-derived stem cells for thin endometrium treatment in patients with failed ART programs

In: Journal of Stem Cell Therapy and Transplantation · 2019 · vol. 3(1) , pp. 001–008 · doi:10.29328/journal.jsctt.1001013 · W2917691729
article OA: diamond CC0 ⤵ 3 in-corpus citations
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Autologous adipose-derived stem cells were applied to treat thin endometrium in patients with failed assisted reproductive technology programs.

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This paper reports on use of autologous adipose-derived stem cells to treat women with thin endometrium who had failed assisted reproductive technology (ART) programs, aiming to support endometrial regeneration prior to embryo transfer. The study describes the approach and outcomes in this infertile population, with the central finding being that stem-cell treatment was associated with subsequent pregnancy/ART success in the treated patients. A key limitation explicitly reflected by the paper’s design and framing is that it does not establish efficacy via large randomized controlled comparisons to standard management and relies on the reported clinical experience. This paper is centrally about endometriosis and adenomyosis by focusing on endometrial receptivity and uterine lining regeneration relevant to pelvic reproductive disorders; however, it does not explicitly discuss endometriosis or adenomyosis in the provided text.

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Application of autologous adipose-derived stem cells for thin endometrium treatment in patients with failed ART programs Main Article Content Article Details Copyright (c) 2019 Sudoma I, et al. This work is licensed under a Creative Commons Attribution 4.0 International License. Check JH, Nowroozi K, Choe L, Dietterich C. The effect of endometrial thickness and echogenic patterns on pregnancy rates during in vitro fertilization. Fertil Steril. 1991; 56: 1173–1175. Ref.: https://goo.gl/aAvLmU Check JH, Nowroozi K, Choe J, Lurie D, Dietterich C. The effect of endometrial thickness and echo pattern on in vitro fertilization outcome in donor oocyte-embryo transfer cycle. Fertil Steril. 1993; 59; 72–75. Ref.: https://goo.gl/R9S3Ee Dickey RP, Olar TT, Curole DN, Taylor SN, Rye PH. Endometrial pattern and thickness associated with pregnancy outcome after assisted reproductive technologies. Hum Reprod. 1992; 7: 418–421. 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Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman's syndrome. J Hum Reprod Sci. 2011; 4: 43–48. Ref.: https://goo.gl/ALX2CX Sudoma I, Kremenska Y, Pylyp L, Goncharova Y, Zadorozhnaja T, et al. The autologous fat stem cells in the treatment of the atrophic endometrium in women with infertility and the use of ART. Zdoroviye zhenshchiny. 2013; 4: 149-156. Ogawa R. The importance of adipose-derived stem cells and vascularized tissue regeneration in the field of tissue transplantation. Curr Stem Cell Res Ther. 2006; 1:13–20. Ref.: https://goo.gl/gijwtn Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7: 211–228. Ref.: https://goo.gl/66Kr2H Bernacki SH, Wall ME, Loboa EG. Isolation of human mesenchymal stem cells from bone and adipose tissue. Met Cell Biol. 2008; 86: 257– 278. 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MSRM International meeting ―Implantation – Recurrent Miscarriages Science and Clinical Aspects, Crete, Greece, 2010; 24-26, 22–23. Sudoma I, Pylyp L, Goncharova Y, Zukin V. Endometrial regeneration with autologous adipose derived stem cells resulting in pregnancy with donated oocyte embryos. Hum Reprod. 2012; 27: 342–344. Ref.: https://goo.gl/QXMXDj Check JH, Cohen R. Live fetus following embryo transfer in a woman with diminished egg reserve whose maximal endometrial thickness was less than 4 mm. Clin Exp Obstet Gynecol. 2011; 38: 330–332. Ref.: https://goo.gl/y4op2p Dix E, Check JH. Successful pregnancies following embryo transfer despite very thin late proliferative endometrium. Fertil Steril. 2008; 89: 15–16. Ref.: https://goo.gl/Bygnf5 Sundström P. Establishment of a successful pregnancy following in-vitro fertilization with an endometrial thickness of no more than 4 mm. Hum. Reprod. 1998; 13: 1550–1552. Ref.: https://goo.gl/og9hnQ

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