A Case of a Retroperitoneal Tumor with a Histological Picture Suggestive of Malignant Transformation Resulting from Endometriosis

N. Iwata, Osamu Okochi, Hidenobu Matsushita, Hiroshi Suzuki, Yuki Hasegawa, Takuma Tsuboi
In: Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) · 2023 · vol. 84(9) , pp. 1534–1540 · doi:10.3919/jjsa.84.1534 · W4393339343
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-26 ⓘ

This report describes a rare retroperitoneal tumor with a histological picture suggestive of malignant transformation, which was ultimately determined to be related to endometriosis.

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This case report describes a 42-year-old woman presenting with right upper abdominal pain during menstruation and a large retroperitoneal mass containing both cystic and solid components. Initial surgical resection revealed histological features resembling adenocarcinoma, leading to a diagnosis of malignant transformation from endometriosis despite negative PET-CT findings for metastasis. Consequently, the patient underwent hysterectomy and bilateral salpingo-oophorectomy followed by adjuvant chemotherapy, resulting in a recurrence-free status at follow-up. This paper is centrally about endometriosis — specifically focusing on the rare malignant transformation of retroperitoneal endometriotic lesions into adenocarcinoma.

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Abstract

子宮内膜症は全身の臓器に起こりうるが後腹膜腔は頻度が少なく，癌化はさらに稀である．症例は42歳の1経妊1経産婦で，月経時の右上腹部痛を主訴に受診し，腹部CTで後腹膜腫瘍を指摘された．MRIで上行結腸の外背側に，内部に液体成分と充実性成分を伴う10×9cm大の囊胞性腫瘤を認めた．CA19-9は2,120U/mL，CA125は116U/mLと上昇を認めた．後腹膜腫瘍摘出術を施行，腫瘍は他臓器への浸潤はなく摘出できた．病理所見では茶褐色液体を含む囊胞病変で，組織学的に婦人科癌に類似したadenocarcinomaの所見であり，総合的に子宮内膜症に関連した後腹膜悪性腫瘍と判断した．PET-CTで明らかな集積は認めず，診断も兼ねて子宮全摘+両側付属器切除+大網部分切除術を追加で施行したが，病理学的に悪性所見は認めなかった．術後，子宮内膜癌の術後化学療法に準じTC療法6コースを施行し，現在無再発経過中である．今回われわれは，子宮内膜症の悪性転化も考えられる組織像を呈した後腹膜腫瘍の1例を経験したので報告する．
Full text 541 characters · extracted from oa-doi-fallback · click to expand
症例 子宮内膜症の悪性転化も考えられる組織像を呈した後腹膜腫瘍の1例 2023 年 84 巻 9 号 p. 1534-1540 詳細 抄録 子宮内膜症は全身の臓器に起こりうるが後腹膜腔は頻度が少なく，癌化はさらに稀である．症例は42歳の1経妊1経産婦で，月経時の右上腹部痛を主訴に受診し，腹部CTで後腹膜腫瘍を指摘された．MRIで上行結腸の外背側に，内部に液体成分と充実性成分を伴う10×9cm大の囊胞性腫瘤を認めた．CA19-9は2,120U/mL，CA125は116U/mLと上昇を認めた．後腹膜腫瘍摘出術を施行，腫瘍は他臓器への浸潤はなく摘出できた．病理所見では茶褐色液体を含む囊胞病変で，組織学的に婦人科癌に類似したadenocarcinomaの所見であり，総合的に子宮内膜症に関連した後腹膜悪性腫瘍と判断した．PET-CTで明らかな集積は認めず，診断も兼ねて子宮全摘+両側付属器切除+大網部分切除術を追加で施行したが，病理学的に悪性所見は認めなかった．術後，子宮内膜癌の術後化学療法に準じTC療法6コースを施行し，現在無再発経過中である．今回われわれは，子宮内膜症の悪性転化も考えられる組織像を呈した後腹膜腫瘍の1例を経験したので報告する． © 2023 日本臨床外科学会

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (8)

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last seen: 2026-05-11T05:28:52.472164+00:00
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