Goserelin--depot preparation of LHRH analogue used in the treatment of endometriosis

R W Shaw, Shaw RW
Progress in clinical and biological research · 1990 · vol. 323 , pp. 383–92 · PMID:2137621 · W2412779394
Non-randomised trial OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Monthly subcutaneous goserelin depot injections for six months effectively desensitized the pituitary, induced hypo-oestrogenism, and relieved endometriosis symptoms by reducing disease deposits.

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Abstract

In summary then, Zoladex depot (Goserelin 3.6 mg) administered monthly for a period of six months proved highly efficacious in achieving endocrine parameters of pituitary desensitization and hypo-oestrogenism. Initial studies treating symptomatic patients with endometriosis shows satisfactory relief of symptoms and significant impact on the disease process as shown by resolution or reduction in number and size of disease deposits. The depot can be given as a subcutaneous injection without the need of local anaesthesia and its duration of action is 28 days. Zoladex depot should offer a suitable, acceptable form of treatment for patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Buserelin Endometriosis Buserelin Buserelin Buserelin Buserelin Buserelin Chemistry, Pharmaceutical Chemistry, Pharmaceutical Delayed-Action Preparations Delayed-Action Preparations Endocrine Glands Endocrine Glands Endocrine Glands Endocrine Glands Endometriosis Endometriosis Endometriosis Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (5)

Source provenance

europepmc
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openalex
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pubmed
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License: CC0 · commercial use OK