Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta

Y.-G. Liu, Ya-Guang Liu, Liu YG, Rajeshwar R. Tekmal, Tekmal RR, Peter Binkley, Peter A Binkley, Binkley PA, Nair HB, Hareesh B. Nair, Robert S. Schenken, Schenken RS, Nameer B. Kirma, Kirma NB
Molecular human reproduction · 2009 · vol. 15(10) , pp. 665–673 · doi:10.1093/molehr/gap043 · PMID:19505996 · PMC2744470 · W2121048892
Lab / animal OA: bronze CC0 ⤵ 27 in-corpus citations
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Transforming growth factor beta 1 induces endometrial epithelial cell invasion and expression of the c-fms gene, suggesting a role for this pathway in endometriosis.

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Abstract

Transforming growth factor beta 1 (TGF-beta1) levels are increased in the peritoneal fluid of endometriosis patients, and endometrial cells express TGF-beta signaling components; however, little is known regarding the role of TGF-beta in endometriosis. Our objective was to examine the effects of TGF-beta1 on (i) the expression of macrophage colony-stimulating factor receptor encoded by the c-fms gene, (ii) transmesothelial invasiveness of endometrial cells, (iii) cellular proliferation and (iv) attachment to peritoneal mesothelial cells (PMCs). Effects of TGF-beta1 on c-fms mRNA expression were determined by real-time RT-PCR and c-fms cell-surface expression by flow cytometry. Effects of TGF-beta1 on the invasiveness of the immortalized endometrial epithelial cell (EEC) line EM42 and primary EECs were examined using a three-dimensional in vitro system modeling the peritoneum. Cellular proliferation and attachment to PMCs were also examined using established techniques. TGF-beta1 had little or no effect on cellular proliferation and endometrial cell attachment to PMCs. TGF-beta1 significantly induced the expression of c-fms mRNA and c-fms cell-surface expression. TGF-beta1 enhanced transmesothelial invasion by EM42 cells and EECs. Antagonists of TGF-beta1 signaling significantly inhibited both the induction of c-fms expression and cellular invasiveness, suggesting that additional studies are warranted to assess the therapeutic potential of TGF-beta antagonists in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Epithelial Cells Receptor, Macrophage Colony-Stimulating Factor Transforming Growth Factor beta Cell Adhesion Cell Adhesion Cell Adhesion Cell Line Cell Line Cells, Cultured Cells, Cultured Chromatin Immunoprecipitation Chromatin Immunoprecipitation Endometrium Endometrium Enzyme Inhibitors Enzyme Inhibitors Enzyme Inhibitors Epithelial Cells Epithelial Cells

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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