Dahuang—Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases

Ya Lei, Xianyun Fu, Minmin Chen, Yongli Yi, Ping Mao, Li Peng, Qu Zhao, Zhao Qu
Frontiers in pharmacology · 2023 · vol. 14 , pp. 1089004 · doi:10.3389/fphar.2023.1089004 · PMID:36969843 · W4323316235
article OA: gold CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Dahuang-Taoren (DT) ameliorates adenomyosis by reducing pathological infiltration, hyperalgesia, and cell invasion, potentially through the inhibition of upregulated Rho GTPases.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper reports that the botanical drug combination Dahuang–Taoren ameliorates adenomyosis by inhibiting Rho GTPases, using molecular approaches to link the treatment’s effects to changes in these signaling pathways. It focuses on mechanistic evidence rather than broad clinical characterization, emphasizing how Rho GTPase inhibition relates to adenomyosis pathology. A key limitation explicitly implied by the provided text is that the study details are not accessible here beyond the headline mechanism, limiting assessment of experimental models, endpoints, and effect magnitude. This paper is centrally about adenomyosis — Dahuang–Taoren is reported to ameliorate adenomyosis via inhibition of Rho GTPases.

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Abstract

Introduction: Dahuang-Taoren (DT) is a classic combination of botanical drugs applied to treat pain-related diseases in ancient China. Today, DT is frequently applied for dysmenorrhea of adenomyosis (AM) in the clinic. Growing evidence indicates Rho GTPases may play an essential role in AM progression. However, the potential mechanism of DT on Rho GTPases in AM remains unclear. Methods: The expressions of Rho GTPases in the patients with AM were evaluated. Further, pituitary transplantation-induced AM mice and the primary AM endometrial stromal cells (AMESCs) were subjected to DT intervention. Results: The results revealed that the expressions of Rho GTPases were significantly upregulated in both AM patients and AM mice. The DT could reduce pathological infiltration, relieve hyperalgesia, and alleviate cytoskeleton remodeling in AM mice. Besides, the migration and invasion of AMESCs were markedly inhibited after exposure to DT. Discussion: These effects may be linked to the decreased Rho GTPases expression. The results may offer a novel explanation of DT against AM.
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Condition tags

adenomyosisdysmenorrhea

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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