Adenomyosis: Current Status and Future Prospects of Drugs Inhibiting Epithelial-Mesenchymal Transition

丽娜 周

doi:10.12677/acm.2026.163762

Adenomyosis: Current Status and Future Prospects of Drugs Inhibiting Epithelial-Mesenchymal Transition

丽娜周

In: Advances in Clinical Medicine · 2026 · vol. 16(03) , pp. 57–63 · doi:10.12677/acm.2026.163762 · W7132843413

article OA: closed CC0

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses current knowledge and future directions for drugs targeting epithelial-mesenchymal transition (EMT) as a treatment strategy for adenomyosis.

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adenomyosis

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References (30)

Abnormal activation of the Wnt3a/β-catenin signaling pathway promotes the expression of T-box transcription factor 3(TBX3) and the epithelial-mesenchymal transition pathway to mediate the occurrence of adenomyosis via openalex
Dahuang—Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases via openalex
Decoding adenomyosis pathogenesis using an assembloid model via openalex
Endometrial cell‑derived exosomes facilitate the development of adenomyosis via the IL‑6/JAK2/STAT3 pathway via openalex
Epithelial-mesenchymal transition as a pathogenetic mechanism of development and progression of adenomyosis via openalex
Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology via openalex
Immune cells and Notch1 signaling appear to drive the epithelial to mesenchymal transition in the development of adenomyosis in mice via openalex
Mechanism Study of Cinnamomi Ramulus and Paris polyphylla Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation via openalex
Melatonin improves pregnancy outcomes in adenomyosis mice by restoring endometrial receptivity via NF-κB/apoptosis signaling via openalex
Metformin Inhibits the Estrogen-mediated Epithelial-Mesenchymal Transition of Ectopic Endometrial Stromal Cells in Endometriosis via openalex
MIR503HG silencing promotes endometrial stromal cell progression and metastasis and suppresses apoptosis in adenomyosis by activating the Wnt/β‑catenin pathway via targeting miR‑191 via openalex
Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial–mesenchymal transition via openalex
Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility via openalex
Proteomic detection of COX-2 pathway-related factors in patients with adenomyosis via openalex
RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis via openalex
Sphingosine 1-phosphate pathway is dysregulated in adenomyosis via openalex
The Effects of Anti-TGF-β1 on Epithelial–Mesenchymal Transition in the Pathogenesis of Adenomyosis via openalex
The Expression of TGF-β1, SMAD3, ILK and miRNA-21 in the Ectopic and Eutopic Endometrium of Women with Endometriosis via openalex
The Inactivation of Hippo Signaling Pathway Promotes the Development of Adenomyosis by Regulating EMT, Proliferation, and Apoptosis of Cells via openalex
β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis via openalex
W2909893490 via openalex
W3092004032 via openalex
W4321441022 via openalex
W4379258996 via openalex
W2983528813 via openalex
W4393320906 via openalex
W4396976025 via openalex
W4404046999 via openalex
W4409689316 via openalex
W4413117461 via openalex

Source provenance

openalex: last seen: 2026-06-04T00:00:01.174412+00:00

License: CC0 · commercial use OK

[1] Abnormal activation of the Wnt3a/β-catenin signaling pathway promotes the expression of T-box transcription factor 3(TBX3) and the epithelial-mesenchymal transition pathway to mediate the occurrence of adenomyosis via openalex

[2] Dahuang—Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases via openalex

[3] Decoding adenomyosis pathogenesis using an assembloid model via openalex

[4] Endometrial cell‑derived exosomes facilitate the development of adenomyosis via the IL‑6/JAK2/STAT3 pathway via openalex

[5] Epithelial-mesenchymal transition as a pathogenetic mechanism of development and progression of adenomyosis via openalex

[6] Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology via openalex

[7] Immune cells and Notch1 signaling appear to drive the epithelial to mesenchymal transition in the development of adenomyosis in mice via openalex

[8] Mechanism Study of Cinnamomi Ramulus and Paris polyphylla Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation via openalex

[9] Melatonin improves pregnancy outcomes in adenomyosis mice by restoring endometrial receptivity via NF-κB/apoptosis signaling via openalex

[10] Metformin Inhibits the Estrogen-mediated Epithelial-Mesenchymal Transition of Ectopic Endometrial Stromal Cells in Endometriosis via openalex

[11] MIR503HG silencing promotes endometrial stromal cell progression and metastasis and suppresses apoptosis in adenomyosis by activating the Wnt/β‑catenin pathway via targeting miR‑191 via openalex

[12] Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial–mesenchymal transition via openalex

[13] Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility via openalex

[14] Proteomic detection of COX-2 pathway-related factors in patients with adenomyosis via openalex

[15] RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis via openalex

[16] Sphingosine 1-phosphate pathway is dysregulated in adenomyosis via openalex

[17] The Effects of Anti-TGF-β1 on Epithelial–Mesenchymal Transition in the Pathogenesis of Adenomyosis via openalex

[18] The Expression of TGF-β1, SMAD3, ILK and miRNA-21 in the Ectopic and Eutopic Endometrium of Women with Endometriosis via openalex

[19] The Inactivation of Hippo Signaling Pathway Promotes the Development of Adenomyosis by Regulating EMT, Proliferation, and Apoptosis of Cells via openalex

[20] β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis via openalex

[21] W2909893490 via openalex

[22] W3092004032 via openalex

[23] W4321441022 via openalex

[24] W4379258996 via openalex

[25] W2983528813 via openalex

[26] W4393320906 via openalex

[27] W4396976025 via openalex

[28] W4404046999 via openalex

[29] W4409689316 via openalex

[30] W4413117461 via openalex