Clear cell carcinoma of the ovary: A study of 59 cases

Mark Crozier, Crozier MA, M A Crozier, L J Copeland, Larry J. Copeland, Copeland LJ, E. G. Silva, Elvio G. Silva, Silva EG, Gershenson DM, David M. Gershenson, D. M. Gershenson, Stringer CA, C A Stringer, C. Allen Stringer
Gynecologic Oncology · 1989 · vol. 35(2) , pp. 199–203 · doi:10.1016/0090-8258(89)90043-7 · PMID:2807010 · W1983389220
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This study analyzed 59 cases of clear cell carcinoma of the ovary to describe clinicopathological features.

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Abstract

Clear cell carcinoma of the ovary accounts for 2 to 3% of all epithelial ovarian neoplasms. Patient profiles, pathological characteristics, and results of treatment are reviewed for 59 patients. The median age was 51. Disease extent at diagnosis was as follows: stage I, 18 patients (31%); stage II, 20 patients (34%); stage III, 15 patients (25%); stage IV, 3 patients (5%); and unknown stage, 3 patients (5%). Endometriosis was identified in 13 patients (22%). Hysterectomy and bilateral salpingo-oophorectomy were performed in 47 patients (80%), unilateral salpingo-oophorectomy in 8 patients (14%), and bilateral salpingo-oophorectomy in 4 patients (7%). Radiotherapy was given to 15 patients (25%), and chemotherapy was given to 42 patients (71%). The overall 2- and 5-year survival rates were 49 and 43%. The median survival was 26 months. Patients with tumors with fewer than 10 mitoses per 10 high-power fields and less than 50% solid areas had significantly longer disease-free intervals. Clear cell tumors are usually diagnosed at an earlier disease stage than the other epithelial ovarian cancers; stage for stage, however, the prognoses are similar.

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MeSH descriptors

Adenocarcinoma Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma Antineoplastic Agents Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols Female Follow-Up Studies Humans Hysterectomy Neoplasm Recurrence, Local Neoplasm Staging Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms

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