A rare case of endometriosis to clear cell ovarian carcinoma: a case report

A rare case of endometriosis to clear cell ovarian carcinoma: a case report DOI: https://doi.org/10.18203/2320-1770.ijrcog20194900Keywords: Aggressive, Chemo resistant, Clear cell carcinoma, Endometriosis, Low survival, Rare, Worse prognosisAbstract Clear cell carcinoma of ovary is a rare tumour with a very low incidence in pregnancy. It is attributed to develop from an existing background of endometriosis. There are very few case reports of the above combination tumours in pregnancy. It is a very aggressive tumour with a worse prognosis and low survival rate because of its peculiar chemo resistant nature. Early detection and effective treatment are the best approach. The treatment options for advanced stages are still under research. Metrics References Otton G, Higgins S, Phillips KA, Quinn M. A case of early-stage epithelial ovarian cancer in pregnancy. Int J Gynecol Cancer. 2001;11(5):413-7. Sayar H, Lhomme C, Verschraegen CF. Malignant adnexal masses in pregnancy. Obstet Gynecol Clin. 2005;32(4):569-93. Crozier MA, Copeland LJ, Silva EG, Gershenson DM, Stringer CA. Clear cell carcinoma of the ovary: a study of 59 cases. Gynecol Oncol. 1989;35(2):199-203. Recio FO, Piver MS, Hempling RE, Driscoll DL. Lack of improved survival plus increase in thromboembolic complications in patients with clear cell carcinoma of the ovary treated with platinum versus nonplatinum‐based chemotherapy. Cancer: Interdiscip Int J Am Cancer Soci. 1996;78(10):2157-63. Pectasides D, Pectasides E, Psyrri A, Economopoulos T. Treatment issues in clear cell carcinoma of the ovary: a different entity? The Oncol. 2006;11(10):1089-94. Nishida M, Watanabe K, Sato N, Ichikawa Y. Malignant transformation of ovarian endometriosis. Gynecol Obstet Invest. 2000;50:18. Behbakht K, Randall TC, Benjamin I, Morgan MA, King S, Rubin SC. Clinical characteristics of clear cell carcinoma of the ovary. Gynecol Oncol. 1998;70(2):255-8. Nishino K, Aoki Y, Amikura T, Obata H, Sekine M, Yahata T, Fujita K, Tanaka K. Irinotecan hydrochloride (CPT-11) and mitomycin C as the first line chemotherapy for ovarian clear cell adenocarcinoma. Gynecol Oncol. 2005;97(3):893-7. Kennedy AW, Biscotti CV, Hart WR, Webster KD. Ovarian clear cell adenocarcinoma. Gynecol Oncol. 1989;32(3):342-9. Skírnisdóttir I, Seidal T, Karlsson MG, Sorbe B. Clinical and biological characteristics of clear cell carcinomas of the ovary in FIGO stages I-II. Int J Oncol. 2005;26(1):177-83. Jenison EL, Montag AG, Griffiths CT, Welch WR, Lavin PT, Greer J, et al. Clear cell adenocarcinoma of the ovary: a clinical analysis and comparison with serous carcinoma. Gynecol Oncol. 1989;32(1):65-71. Kobayashi F, Monma C, Nanbu K, Konishi I, Sagawa N, Mori T. Rapid growth of an ovarian clear cell carcinoma expressing LH/hCG receptor arising from endometriosis during early pregnancy. Gynecol Oncol. 1996;62(2):309-13. Sugiyama T, Nishida T, Kataoka A, Okura N, Iwanaga S, Yakushiji M. A pregnant woman with clear cell adenocarcinoma of the ovary arising from endometriosis and with benign and borderline adenofibroma of the clear cell and endometrioid types. Eu J Obstet Gynecol Repro Biol. 1997;72(1):47-50. Nagano H, Sawai H, Oomoto H. A case of pregnancy associated clear cell carcinoma, making it difficult to diagnose (in Japanese). Chugoku Shikoku Dist J Jpn Soc Obstet Gynecol. 1999;47:231-2. Satoh K, Matsushima T, Tsukada K, Konishi H, Ishihara K, et al. A case of pregnancy associated with clear cell carcinoma (in Japanese). Kanto J Obstet Gynecol. 2000;37:295. Makrydimas G, Sotiriadis A, Paraskevaidis E, Pavlidis N, Agnantis N, et al. Clear cell ovarian carcinoma in a pregnant woman with a history of infertility, endometriosis and unsuccessful IVF treatment. Eur J Gynaecol Oncol. 2003;24:438-41. Hwang CS, Park SY, Yu SH, Park JY, Park CT. Hypercalcemia induced by ovarian clear cell carcinoma producing all transcriptional variants of parathyroid hormone-related peptide gene during pregnancy. Gynecol Oncol. 2006;103:740-4. Matsui H, Saito M, Tanuma Y. A case of pregnancy associated with ovarian clear cell carcinoma. Tokyo J Obstet Gynecol. 2010;59:389-92. Shin JW, Ku CH, Lee HH, Kim SY. Clear cell carcinoma of ovary cervix affecting the women with early pregnancy. Acta Obstet Gynecol Jpn. 2012;64:900. Goff BA, de la Cuesta RS, Muntz HG, Fleischhacker D, Ek M, Rice LW, et al. Clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy in stage III disease. Gynecol Oncol. 1996;60(3):412-7.