The expression of cyclooxygenase-2 and vascular endothelial growth factor in the endometrium during the peri-implantation period in women with and without polyps

Yi‐Xiu Xiao, Y Xiao, X Peng, Xiaoyan Peng, N Ma, Ning Ma, Tin Chiu Li, T. C. Li, E Xia
Human fertility (Cambridge, England) · 2014 · vol. 17(1) , pp. 67–71 · doi:10.3109/14647273.2013.868933 · PMID:24471989 · W2095695593
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This study found that cyclooxygenase-2 and vascular endothelial growth factor expression in endometrial glands was lower in women with endometrial polyps compared to controls.

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Abstract

OBJECTIVE: This prospective study was designed to determine whether the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in the endometrial tissue obtained from the peri-implantation period of women with endometrial polyp (EP) differs from that of control subjects without a polyp. METHODS: Endometrial samples were collected from 30 patients with EP and 30 control subjects without EP, in the mid-secretory phase. The expression of COX-2 and VEGF in the endometrium was examined with the use of immunohistochemistry. RESULTS: COX-2 and VEGF were predominantly expressed in endometrial glands. The expression of COX-2 and VEGF in the endometrium obtained from women with EP was lower than that of control subjects. CONCLUSION: The reduced expression of COX-2 and VEGF in the endometrium of women with EP may account for the association between EP and infertility.

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Condition tags

infertility

MeSH descriptors

Cyclooxygenase 2 Endometrium Polyps Uterine Diseases Vascular Endothelial Growth Factor A Adult Cyclooxygenase 2 Cyclooxygenase 2 Endometrium Female Gene Expression Regulation Gene Expression Regulation Humans Polyps Pregnancy Prospective Studies Uterine Diseases Uterine Diseases Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A

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