Endometriosis Model Development in Swine

Julianne Siegel, Siegel J, Kolata R, Ron Kolata
Lab animal · 2003 · vol. 32(4) , pp. 41–45 · doi:10.1038/laban0403-41 · PMID:19753751 · W2004396215
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This paper describes the development of a swine model for endometriosis to facilitate the evaluation of laparoscopic diagnostic and treatment methods.

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This paper addresses the scarcity of appropriate animal models for endometriosis by describing the development of a swine model. The authors detail a methodology that enables researchers to evaluate laparoscopic techniques and instruments specifically for diagnosing and treating the condition in pigs. This approach provides a relevant large-animal system for preclinical testing of surgical interventions. This paper is centrally about endometriosis, focusing on the creation of a swine model to facilitate the study of diagnostic and therapeutic laparoscopic procedures.

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Abstract

Despite the prevalence of endometriosis in the human population, there is a shortage of animal models for studying it. The authors describe the development of a swine model of endometriosis that allows researchers to evaluate laparoscopic techniques and instruments for diagnosing and treating the condition.
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Abstract

Despite the prevalence of endometriosis in the human population, there is a shortage of animal models for studying it. The authors describe the development of a swine model of endometriosis that allows researchers to evaluate laparoscopic techniques and instruments for diagnosing and treating the condition. This is a preview of subscription content, access via your institution Access options Similar content being viewed by others

References

Corson, S. Endometriosis: The Enigmatic Disease (Essential Medial Information Systems, Durant, 1992). Freeman, L. Veterinary Endosurgery (Mosby, St. Louis, 1999). Institute of Laboratory Animal Resources, National Research Council. Guide for the Care and Use of Laboratory Animals (National Academy Press, Washington, DC, 1996). Garbers, D.L. & First, N.L. The effects of injected oestradiol-17-β, progesterone and dietary ICI 33828 on ovarian and pituitary functions in the sow and gilt. J. Reprod. Fertil. 20, 451–464 (1969). Gooneratne, A., Hartmann, P.E., McCauley, I. & Martin, C.E. Control of parturition in the sow using progesterone and prostaglandin. Aust. J. Biol. Sci. 32, 587–595 (1979). Petrucco, O.M. et al. Ablation of endometriotic implants in rabbits by hematoporphy derivative photoradiation therapy using the gold vapor laser. Lasers Surg. Med. 10, 344–348 (1990). Cummings, A.M. & Metcalf, J.L. Effects of estrogen, progesterone, and methoxychlor on surgically induced endometriosis in rats. Fundam. Appl. Toxicol. 27, 287–290 (1995). D'Hooghe, T.M. et al. Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis). Am. J. Obstet. Gynecol. 173, 125–134 (1995).

Acknowledgements

The authors thank Mary K. Reinhard, DVM, ACVP, ACLAM for the histological evaluation. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Siegel, J., Kolata, R. Endometriosis Model Development in Swine. Lab Anim 32, 41–45 (2003). https://doi.org/10.1038/laban0403-41 Received: Accepted: Issue date: DOI: https://doi.org/10.1038/laban0403-41

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Endometrium Swine, Miniature Animals Drug Administration Schedule Drug Therapy, Combination Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Estradiol Female Progesterone Progesterone Progesterone Sexual Maturation

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (12)

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