Ablation of endometriotic implants in rabbits by hematoporphyrin derivative photoradiation therapy using the gold vapor laser

O M Petrucco, M Sathananden, Muttukrishna Sathananden, M. Petrucco, M F Petrucco, S Knowles, Simon Knowles, L McKenzie, Ian J. Forbes, I J Forbes, Prudence A. Cowled, P A Cowled, W E Keye, William E. Keye
Lasers in surgery and medicine · 1990 · vol. 10(4) , pp. 344–348 · doi:10.1002/lsm.1900100407 · PMID:2392017 · W2065328097
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Hematoporphyrin derivative photoradiation therapy using a gold vapor laser effectively ablated induced endometriotic implants in rabbits without damaging surrounding tissues.

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Abstract

In a rabbit model, endometriotic lesions were utilized to study hematoporphyrin derivative (HPD) uptake and the effect of photoradiation using the gold vapor laser. Morphological studies confirmed successful induction of ectopic endometrial growth and the lesions displayed preferential HPD uptake compared to normal intraperitoneal structures. Gold vapor laser irradiation of the lesions in HPD pretreated animals produced necrosis of the endometriotic lesions leaving surrounding tissues healthy. Results from this study suggest that HPD-mediated photodynamic therapy may be a suitable means of treating endometriosis in the human.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Hematoporphyrins Laser Therapy Phototherapy Uterine Neoplasms Animals Endometriosis Endometriosis Endometriosis Female Gold Gold Hematoporphyrins Hematoporphyrins Phototherapy Rabbits Uterine Neoplasms Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

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