Ablation of endometriotic implants in rabbits by hematoporphyrin derivative photoradiation therapy using the gold vapor laser

Petrucco OM, O. M. Petrucco, M Sathananden, Sathananden M, Muttukrishna Sathananden, M F Petrucco, M. Petrucco, Petrucco MF, Knowles S, S Knowles, Simon Knowles, L. McKenzie, McKenzie L, I J Forbes, Ian J. Forbes, Forbes IJ, Cowled PA, P A Cowled, Prudence A. Cowled, Keye WE, W E Keye, William E. Keye
Lasers in surgery and medicine · 1990 · vol. 10(4) , pp. 344–348 · doi:10.1002/lsm.1900100407 · PMID:2392017 · W2065328097
Lab / animal OA: closed CC0 ⤵ 5 in-corpus citations
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Hematoporphyrin derivative photoradiation therapy using a gold vapor laser effectively ablated induced endometriotic implants in rabbits without damaging surrounding tissues.

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Abstract

In a rabbit model, endometriotic lesions were utilized to study hematoporphyrin derivative (HPD) uptake and the effect of photoradiation using the gold vapor laser. Morphological studies confirmed successful induction of ectopic endometrial growth and the lesions displayed preferential HPD uptake compared to normal intraperitoneal structures. Gold vapor laser irradiation of the lesions in HPD pretreated animals produced necrosis of the endometriotic lesions leaving surrounding tissues healthy. Results from this study suggest that HPD-mediated photodynamic therapy may be a suitable means of treating endometriosis in the human.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Hematoporphyrins Laser Therapy Laser Therapy Phototherapy Uterine Neoplasms Animals Animals Endometriosis Endometriosis Endometriosis Endometriosis Female Female Gold Gold Gold Hematoporphyrins Hematoporphyrins Hematoporphyrins

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (11)

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