Experimental Model of Intestinal Endometriosis: Pilot Study

Lucio Rossini, Rogério Saad-Hossne, Rodrigo Zago, Annacarolina Silva, Annacarolina da Silva, Tabatha D. Kalenski, Marcelo Averbach
In: British Journal of Applied Science & Technology · 2015 · vol. 7(5) , pp. 449–455 · doi:10.9734/bjast/2015/13615 · W2318758936
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This pilot study created an experimental model of intestinal endometriosis in pigs by implanting endometrial fragments in the rectal wall, allowing for visualization via transrectal ultrasonography.

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Abstract

Aims: The objective of this study is to create an experimental model of intestinal endometriosis in pigs, which might allow better understanding of deep infiltrating endometriosis and development of new treatment techniques. As secondary objective, we intend to create endometrial implants accessible by transrectal ultrasonography (TRUS). Study Design: Surgical experimental study in swine. Place and Duration of Study: This study was performed at the Instituto de Ensino e Pesquisa do Hospital Srio-Libans, So Paulo, Brazil, between January 2012 and December 2012. Methodology: Two sexually mature female minipigBR pigs underwent two laparotomies (each animal). The first laparotomy was performed to implant two fragments of autologous endometrium in the rectal wall. The second one was performed thirty days later to visualize, measure and obtain Original Research Article tissue of the site of the implants for histopathology study. A TRUS study was performed prior to the second surgery. The Institution's Animal Utilization Study Committee approved the study.

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Condition tags

endometriosisdie_deep_infiltrating

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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