Postgraduate medical journal

A case of endometriosis of the colon is presented. The incidence, symptomatology and treatment are discussed.

The differing aspects of fibrocystic disease are presented. The various histological components making up the breast account for the variegated presentation of symptoms and findings. Pain, tenderness and nodularity represent the greatest pr…

Based on "second look" pelviscopic control in 438 cases of pelvic endometrosis, additional hormonal antigonadotrophin therapy with danazol represents the most effective treatment for endometriosis. The rationale is well explained by Dmowski…

Danazol as a powerful antigonadotrophin is a logical mode of treatment for patients with premenstrual symptoms. Its preliminary use in a dose 200-800 mg daily is reported. Two groups of patients were treated and of 12 patients with severe s…

A group of 42 patients with gynaecomastia were treated with danazol. There were 31 adults and 11 cases of pubertal gynaecomastia. Dosage schedules in adults were 300-600 mg a day and in adolescents 200-300 mg a day. In the 31 adults, marked…

Danazol, a new synthetic steroid, was administered at a dose of 400 mg daily for two months to 16 premenopausal women with chronic cystic mastopathy. The clinical and hormonal effects (serum luteinizing hormone (LH), follicle-stimulating ho…

Danazol is effective in the treatment of endometriosis. Individual patient response is very variable as is dosage requirement. The appropriate dose for maintenance therapy for any particular patient is best determined by a trial and error m…

A longitudinal study of thyroid function during danazol treatment was performed in 18 women. Serum concentrations of thyroid stimulating hormone (TSH), thyroxine (T4), tri-iodothyronine (T3), free T4-and free T3 index as well as thyroid hor…

Twenty patients, mostly with severe endometriosis and infertility, were treated with danazol 600 mg daily for six months. Clinical investigation and laboratory tests were done monthly. During treatment most clinical findings and symptoms of…

The authors present a clinical study of 62 infertile patients with endometriotic lesions diagnosed in all cases by laparoscopy. The large variety of lesions and the high incidence in this series of tumorous or tubal lesions, led in 39 cases…

Since 1975, 65 cases of endometriosis have been treated with danazol, and in an attempt to retain effective management with a minimum of side effects, three different dosage scheme providing 600 mg (Group 1) 400 mg (Group 2) or 200 mg daily…

The effect of danazol in a dose of 600 mg a day was studied in 20 women with moderate or severe endometriosis. The clinical effect was found to be excellent and repeat laparoscopy after about 6 months treatment revealed a marked regression …

In a comparison of danazol, and mestranol with norethynodrel (Enavid, Searle) in the treatment of endometriosis danazol was shown to be superior. Danazol is however relatively ineffective when large tumours or extensive adhesions are presen…

Preliminary results are presented on the effect of 400, 200 and 100 mg of daily danazol on measured menstrual blood loss, in women with menorrhagia. Both 400 and 200 mg daily effectively suppressed menstrual blood loss, 400 mg reducing mens…

The management, investigation and treatment of 12 children with precocious puberty is described. Danazol, a synthetic derivative of ethisterone, has been used over a period of 3 1/2 years. Its clinical, endocrine and biochemical effects hav…

The preliminary results of a double-blind randomized cross-over trial of danazol versus placebo in patients with severe cyclical breast pain are reported. Though numbers are small at present, the results are encouraging.

In order to investigate the possible stimulatory effect of danazol on fertility, a randomized clinical trial was performed on 40 women with unexplained infertility. Twenty-one women received 200 mg danazol daily for 100 days and 19 women re…

A case of intrafollicular and unruptured ovarian pregnancy associated with intrauterine device which meets the rigid criteria of Spiegelberg (1878) is presented. Clinically, unruptured cases can be confused with ovarian cysts. Intrauterine …

A case of malignant mucocele of the appendix caused by constriction of its base at the neck of a femoral hernial sac is described. No similar case has been found after a careful search of the literature.

A technique for laparoscopy is described and the indications for operation and the laparoscopic findings in 406 patients detailed.

The techniques of radiological examination of the small bowel are considered. The importance of the routine barium meal and follow-through examination is stressed. The vast majority of lesions present a diagnostic problem in interpretation …