Clinical and biochemical experiences with danazol in the treatment of endometriosis in cases with female infertility.

Liselotte Mettler, L Mettler, Mettler L, K. Semm, Semm K
Postgraduate medical journal · 1979 · vol. 55 Suppl 5 , pp. 27–32 · PMID:537950 · W2460358511
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Danazol combined with a three-step surgical approach significantly improved remission rates and pregnancy rates in women with endometriosis and infertility compared to progestogen therapy.

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Abstract

Based on "second look" pelviscopic control in 438 cases of pelvic endometrosis, additional hormonal antigonadotrophin therapy with danazol represents the most effective treatment for endometriosis. The rationale is well explained by Dmowski and Scommegna (1976). As endocrine treatment alone cannot control severe cases of endometriosis, in recent years a combined 3-step surgical-endocrine-surgical therapy, with thermocoagulation of endometriotic foci, cyst wall resection of endometriomas and consecutive thermocoagulation has proved to be the optimal therapy for endometriosis in general and especially in cases of sterilty. While additional progestogen therapy resulted in a 60% rate of remission of the symptoms of endometriosis, danazol gave a 90% success rate in the 3-step therapy. This 3-step therapy avoids many cases of radical surgery during the reproductive age in women with endometriosis. The pregnancy rate of 312 patients treated between 1976 and 1978 with danazol amounted to 45% compared with a pregnancy rate of 32% treated with lynestrenol and laparoscopy.

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Condition tags

endometriosisinfertility

MeSH descriptors

Danazol Endometriosis Genital Neoplasms, Female Infertility, Female Pregnadienes Danazol Endometriosis Endometriosis Endometriosis Female Genital Neoplasms, Female Genital Neoplasms, Female Genital Neoplasms, Female Gonadotropins, Pituitary Gonadotropins, Pituitary Humans Infertility, Female Infertility, Female Pregnadienes Pregnancy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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