Clinical and biochemical experiences with danazol in the treatment of endometriosis in cases with female infertility
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Danazol combined with a three-step surgical approach significantly improved remission rates and pregnancy rates in women with endometriosis and infertility compared to progestogen therapy.
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Abstract
Based on "second look" pelviscopic control in 438 cases of pelvic endometrosis, additional hormonal antigonadotrophin therapy with danazol represents the most effective treatment for endometriosis. The rationale is well explained by Dmowski and Scommegna (1976). As endocrine treatment alone cannot control severe cases of endometriosis, in recent years a combined 3-step surgical-endocrine-surgical therapy, with thermocoagulation of endometriotic foci, cyst wall resection of endometriomas and consecutive thermocoagulation has proved to be the optimal therapy for endometriosis in general and especially in cases of sterilty. While additional progestogen therapy resulted in a 60% rate of remission of the symptoms of endometriosis, danazol gave a 90% success rate in the 3-step therapy. This 3-step therapy avoids many cases of radical surgery during the reproductive age in women with endometriosis. The pregnancy rate of 312 patients treated between 1976 and 1978 with danazol amounted to 45% compared with a pregnancy rate of 32% treated with lynestrenol and laparoscopy.
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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
Cited by (9)
- The treatment of mild endometriosis with laser laparoscopy: a two-step treatment analysis of patients whose primary therapy was successful 2006
- The success of laser laparoscopy in the treatment of endometriosis: a two-step analysis 2001
- Minimal/mild endometriosis and infertility. A review 1989
- Nd:YAG laser ablation of early pelvic endometriosis: a report of 61 cases 1987
- Medical treatment of endometriosis in infertile patients 1983
- Three step medical and surgical treatment of endometriosis 1983
- Danazol in the treatment of endometriosis 1980
- Endometriosis--continuing conundrum 1980
- Endometriosis—continuing conundrum 1980
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