Effect of danazol on thyroid function in women.
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Danazol therapy in women significantly decreased thyroxine binding globulin and altered thyroid hormone levels within normal ranges, prompting consideration for interpreting thyroid function tests.
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Abstract
A longitudinal study of thyroid function during danazol treatment was performed in 18 women. Serum concentrations of thyroid stimulating hormone (TSH), thyroxine (T4), tri-iodothyronine (T3), free T4-and free T3 index as well as thyroid hormone binding globulin (TBG) were measured before and during 6 months therapy. Thyroxine binding globulin showed a marked decrease to one third of the pretreatment level. All the hormones showed significant alterations within the normal ranges for this group. T3 and T4 decreased slightly and the free T4 and free T3 index showed an increase. TSH decreased from 2.4 +/- 0.6 to 1.7 +/- 0.3 mIU/l. The observed hormonal changes were most likely induced by the decreased TBG concentrations and were probably without pathological significance. However these changes must be kept in mind when thyroid function tests from patients with danazol are evaluated.
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Cited by (4)
- The influence of danazol on pituitary function and on the ovarian follicular hormone secretion in premenopausal women 1984
- Danazol treatment of severely symptomatic fibrocystic breast disease and long‐term follow‐up—the Hjørring project 1984
- Effect of danazol on thyroid function in postmenopausal women 1984
- Endometriosis<b>Laparoscopy—Diagnostic and Therapeutic Approaches</b> 1997
Cited by (4)
- Endometriosis<b>Laparoscopy—Diagnostic and Therapeutic Approaches</b> 1997
- The influence of danazol on pituitary function and on the ovarian follicular hormone secretion in premenopausal women 1984
- Effect of danazol on thyroid function in postmenopausal women 1984
- Danazol treatment of severely symptomatic fibrocystic breast disease and long‐term follow‐up—the Hjørring project 1984
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- europepmc
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